FKBP4
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Official Full Name
FK506 binding protein 4, 59kDa -
Overview
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008] -
Synonyms
FKBP4;FK506 binding protein 4, 59kDa;HBI;p52;Hsp56;FKBP51;FKBP52;FKBP59;PPIase;peptidyl-prolyl cis-trans isomerase FKBP4;rotamase;HSP binding immunophilin;51 kDa FK506-binding protein;FK506-binding protein 4 (59kD);T-cell FK506-binding protein, 59kD;peptidylprolyl cis-trans isomerase
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Mouse
- Wheat Germ
- In Vitro Cell Free System
- His
- His&GST
- Non
- His&Fc&Avi
- Flag
- GST
- Myc&DDK
- His&PA
Involved Pathway
FKBP4 involved in several pathways and played different roles in them. We selected most pathways FKBP4 participated on our site, such as Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Estrogen signaling pathway | ITPR3,MAP2K1,SRC,PRKACG,HSPA2,AKT1,ATF6B,CALM3,GNAI2,SHC3 |
Protein Function
FKBP4 has several biochemical functions, for example, ATP binding,FK506 binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP4 itself. We selected most functions FKBP4 had, and list some proteins which have the same functions with FKBP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FK506 binding | FKBP1B,FKBP14,FKBP10B,FKBPL,FKBP1AB,FKBP7,FKBP11,TTC9B,FKBP10,FKBP6 |
| GTP binding | SEPT4,SEPT8A,RRAGCB,RND3B,ERAL1,ARL4AB,ERAS,RAB11BB,GMPPAB,RRAD |
| protein binding | TRIM13,DDX21,INSIG1,ATP6V0C,TRIP10,MX1,TRIM37,DDX23,SERINC1,EIF1AX |
| protein binding, bridging | AMFR,SPRR1B,TIRAP,BFAR,VPS18,FGB,CAV1,TJP2,ADAP2,FSCN2B |
| heat shock protein binding | LMAN2,PPP5C,PPID,HSPA6,BCOR,TOMM34,SSUH2RS1,LIMK1,APAF1,GM5506 |
| copper-dependent protein binding | ATP7A,ATOX1 |
| phosphoprotein binding | DPYSL3,SAG,PIH1D1,RB1,PLAT,GPRIN1,TBL2,RRAGA,YWHAB,SFN |
| ATP binding | STK33,SLC27A5,TSSK2,MAPK10,IARS,RPS6KA6,KIF15,MTPAP,GRK1B,NEK2 |
| tau protein binding | SNCA,AATF,SERPINB1A,DYRK1A,S100B,HDAC6,APOE,PPP2R2A,BIN1 |
Interacting Protein
FKBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP4.
S100a1;HSP90AA1;S100A6;S100A2
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