FGFBP1
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Official Full Name
fibroblast growth factor binding protein 1 -
Overview
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. -
Synonyms
FGFBP1;fibroblast growth factor binding protein 1;fibroblast growth factor-binding protein 1;FGFBP;HBP17;17 kDa heparin binding growth factor binding protein;FGF binding protein 1;FGF BP;FGF BP1;Fibroblast growth factor binding protein 1 precursor;FGF-binding protein 1;17 kDa HBGF-binding protein;heparin-binding growth factor binding protein;17 kDa heparin-binding growth factor-binding protein;FGF-BP;FGF-BP1;FGFBP-1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mammalian cells
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- Non
- His&Fc&Avi
- GST
Involved Pathway
FGFBP1 involved in several pathways and played different roles in them. We selected most pathways FGFBP1 participated on our site, such as FGFR2 ligand binding and activation,FGFR2b ligand binding and activation,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by FGFR2 | FGFBP2,FGFBP3 |
| FGFR2 ligand binding and activation | FGFBP2,FGFBP3 |
| Signal Transduction | OPN4.1,OR52B4,RTN4A,FABP11A,RHOV,STAM2,IFT172,QRFPR,ARHGAP29B,AES |
| FGFR2b ligand binding and activation | FGFBP2,FGFBP3 |
| Signaling by FGFR | KAL1,KAL1A,FGFBP3,FGFBP2 |
Protein Function
FGFBP1 has several biochemical functions, for example, fibroblast growth factor binding,heparin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFBP1 itself. We selected most functions FGFBP1 had, and list some proteins which have the same functions with FGFBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | ITGAM,PCOLCE,SLIT3,GM4980,CCL23,LIPC,C6orf25,MSTN,KNG1,PDCD5 |
| protein binding | DCDC2,C5orf20,FLT3,PIP4K2B,LPXN,PPP2R2A,GTF2B,CCDC120,PTK7,RBM39 |
| fibroblast growth factor binding | FIBP,FGFR3,RPS2,GPC1,RPS19,FGFR1A,FGFR2,FGFRL1,CEP57,THBS1 |
Interacting Protein
FGFBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFBP1.
FGF2;UBQLN4;ssrna_ug
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