FFAR1
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Official Full Name
free fatty acid receptor 1 -
Overview
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. -
Synonyms
FFAR1;free fatty acid receptor 1;G protein coupled receptor 40 , GPR40;FFA1R;FFAR 1;G protein coupled receptor 40;GPR 40;G protein-coupled receptor 40;G-protein coupled receptor 40;GPR40;GPCR40
Recombinant Proteins
- Human
- Rat
- Mouse
- Mesocricetus auratus
- Macaca fascicularis
- Mus musculus
- E.coli
- HEK293
- Mammalian Cells
- GST
- Non
- His
- Flag&His
- Avi&Fc&His
Involved Pathway
FFAR1 involved in several pathways and played different roles in them. We selected most pathways FFAR1 participated on our site, such as Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with FFAR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin secretion | ADCYAP1,SNAP25,FXYD2,ITPR3,PRKCG,ATF4,GLP1R,CAMK2D,PLCB4,INS |
Protein Function
FFAR1 has several biochemical functions, for example, G-protein coupled receptor activity,bioactive lipid receptor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FFAR1 itself. We selected most functions FFAR1 had, and list some proteins which have the same functions with FFAR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid binding | APOA4,LTC4S,MTTP,SH3GLB1,FABP7B,RBP2A,ACBD7,RASGRP2,FAM123B,SEC14L4 |
| guanyl-nucleotide exchange factor activity | DOCK8,EIF2B5,P2RY12,ITSN1,ARHGEF17,DENND1C,DOCK1,GAPVD1,FGD6,RASGRP2 |
| G-protein coupled receptor activity | DRD4-RS,RXFP2A,OR5B2,P2RY6,RXFP2B,GNRHR1,TAS2R138,TAS2R202,EMR3,EDNRBA |
Interacting Protein
FFAR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FFAR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FFAR1.
Resources
Research Area
Lipid and Fatty Acid TransportPancreatic Endoderm Cell Markers
Diabetic Peripheral Neuropathy
Bioactive Lipid G Protein-Coupled Receptors
Endodermal Lineage Markers
Related Services
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References
- Teutsch, CA; Panse, M; et al. Detection of free fatty acid receptor 1 expression: the critical role of negative and positive controls. DIABETOLOGIA 57:776-780(2014).
- Nagatake, T; Fujita, H; et al. Enteroendocrine Cells Are Specifically Marked by Cell Surface Expression of Claudin-4 in Mouse Small Intestine. PLOS ONE 9:-(2014).
- Hirasawa, A; Itsubo, C; et al. Production and characterization of a monoclonal antibody, against GPR40 (FFAR1; free fatty acid receptor 1). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 365:22-28(2008).
