FBXW8
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Official Full Name
F-box and WD repeat domain containing 8 -
Overview
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
FBXW8;F-box and WD repeat domain containing 8;F box and WD 40 domain protein 8 , F box only protein 29 , FBXO29;F-box/WD repeat-containing protein 8;FBW6;FBW8;FBX29;F box/WD repeat containing protein 8;F box and WD40 domain containing protein 8;F box only protein 29;FBXO29;FBXW6;F-box only protein 29;F-box and WD-40 domain protein 8;F-box and WD-40 domain-containing protein 8
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXW8-3977H | Recombinant Human FBXW8 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXW8-5781M | Recombinant Mouse FBXW8 Protein | Mammalian Cells | Mouse | His |
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| FBXW8-6446Z | Recombinant Zebrafish FBXW8 | Mammalian Cells | Zebrafish | His |
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| FBXW8-3180M | Recombinant Mouse FBXW8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FBXW8-3180M-B | Recombinant Mouse FBXW8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
FBXW8 involved in several pathways and played different roles in them. We selected most pathways FBXW8 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | TCEB2,SMURF1,RHOBTB1,UBE2NA,SIAH1,CDC20,MGRN1B,RHOBTB2A,UBE2Z,CBLC |
Protein Function
FBXW8 has several biochemical functions, for example, protein binding,contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW8 itself. We selected most functions FBXW8 had, and list some proteins which have the same functions with FBXW8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin-protein transferase activity | DBN1,KCTD13,RBX1,KLHL9,RNF40,RNF20,KBTBD13,UBE2C,CCIN,KLHL32 |
| protein binding | FES,POT1A,RAB35,SP3,Apba1,ZNF350,GSPT2,SNRPA1,HJURP,MAP4K4 |
Interacting Protein
FBXW8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW8.
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