FBXL20
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Official Full Name
F-box and leucine-rich repeat protein 20 -
Overview
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif.;SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as;protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination;targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)). -
Synonyms
FBXL20;F-box and leucine-rich repeat protein 20;F-box/LRR-repeat protein 20;Fbl2;Fbl20;MGC15482;F-box protein FBL2;FLJ21037;DKFZp564O2364
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXL20-12778H | Recombinant Human FBXL20, His-tagged | E.coli | Human | His | C-term-357a.a. | |
| FBXL20-2287R | Recombinant Rat FBXL20 Protein | Mammalian Cells | Rat | His |
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| FBXL20-3899H | Recombinant Human FBXL20 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXL20-5720M | Recombinant Mouse FBXL20 Protein | Mammalian Cells | Mouse | His |
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| FBXL20-1944R | Recombinant Rat FBXL20 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| FBXL20-1944R-B | Recombinant Rat FBXL20 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| FBXL20-3145M | Recombinant Mouse FBXL20 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FBXL20-3145M-B | Recombinant Mouse FBXL20 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FBXL20-4969HF | Recombinant Full Length Human FBXL20 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 436 amino acids |
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Involved Pathway
FBXL20 involved in several pathways and played different roles in them. We selected most pathways FBXL20 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FBXL20 has several biochemical functions, for example, contributes_to ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL20 itself. We selected most functions FBXL20 had, and list some proteins which have the same functions with FBXL20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin protein ligase activity | FBXL2,FBXL3A,FBXL14,FBXL3B,UBXN6,FBXL15,CUL4B,C10orf46,CUL1B,KDM2BA |
Interacting Protein
FBXL20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL20 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL20.
Resources
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References
- Xiao, J; Zhang, T; et al. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. GENES & DEVELOPMENT 29:184-196(2015).
- Zhu, JJ; Deng, SS; et al. FBXL20 acts as an invasion inducer and mediates E-cadherin in colorectal adenocarcinoma. ONCOLOGY LETTERS 7:2185-2191(2014).
