EXT1
-
Official Full Name
exostosin 1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Mus musculus
- Bovine
- Papio anubis (Olive baboon)
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi&Fc&His
Involved Pathway
EXT1 involved in several pathways and played different roles in them. We selected most pathways EXT1 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | EXTL1,HS6ST2,HS6ST1,HS6ST3,GLCEB,EXT2,EXT1B,XYLT1,GLCE,NDST1 |
| Metabolic pathways | DNMT4,AADAT,IMPDH1B,NDUFC2,PNAT3,GAA,SDHA,ALDH3A1,MGAT3A,CTPS2 |
Protein Function
EXT1 has several biochemical functions, for example, N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity,acetylglucosaminyltransferase activity,glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EXT1 itself. We selected most functions EXT1 had, and list some proteins which have the same functions with EXT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetylglucosaminyltransferase activity | HEXB,GALNT18A,LARGE,PIGB,XYLT1,OGT,HEXA,4931440L10Rik,B3GALNT2,MGAT1A |
| N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity | EXT2,EXT1B,EXT1C,EXT1A |
| protein homodimerization activity | GRHPR,HLCS,DMRT2A,IZUMO3,PON3,MLL1,ERBB4,CDH13,ASGR1,NOG |
| protein heterodimerization activity | PPARD,CEBPA,IKBKG,DMRT3,JAM3,GABPA,TAF12,PRSS28,SDCBP,VAPA |
| transferase activity, transferring glycosyl groups | PYGMB,PNP5A,UGT2B3,GGTA1,B3GNTL1,DPAGT1,PNP6,UGT5C2,PYGMA,EXT2 |
| glucuronosyltransferase activity | UGT2A4,UGT5C1,UGT2B15,UGT1A2,UGT1B1,UGT5D1,UGT1A7C,EXT2,B3GAT3,UGT5A2 |
| heparan sulfate N-acetylglucosaminyltransferase activity | EXT2 |
| glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity | EXT2,EXT1A,EXTL1,EXT1C,EXT1B |
| metal ion binding | TCN2,CAR6,LOXL2B,MBNL1,AGAP2,HBBE2,MYCBP2,NOTCH1A,RSAD2,STAC3 |
Interacting Protein
EXT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXT1.
MYH1;CNTF;OSTF1;fdhF;Kif2c
Resources
Related Services
Related Products
References
- Nadanaka, S; Kagiyama, S; et al. Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes. BIOCHEMICAL JOURNAL 454:133-145(2013).
- Multhaupt, HAB; Couchman, JR; et al. Heparan Sulfate Biosynthesis: Methods for Investigation of the Heparanosome. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:908-915(2012).
