EVI1
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Official Full Name
MECOM MDS1 and EVI1 complex locus -
Overview
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. -
Synonyms
EVI1;MDS1;PRDM3;MGC97004;MDS1-EVI1;MGC163392;AML1-EVI-1;MDS1 and EVI1 complex locus protein EVI1;oncogene EVI1;OTTHUMP00000213163;OTTHUMP00000213164;OTTHUMP00000213165;OTTHUMP00000213187;OTTHUMP00000213191;OTTHUMP00000213192;zinc finger protein Evi1;AML1-EVI-1 fusion protein;MDS1 and EVI1 complex locus protein MDS1;myelodysplasia syndrome-associated protein 1;ecotropic virus integration site 1 protein homolog
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Involved Pathway
EVI1 involved in several pathways and played different roles in them. We selected most pathways EVI1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EVI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
EVI1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by EVI1 itself. We selected most functions EVI1 had, and list some proteins which have the same functions with EVI1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
EVI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EVI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EVI1.
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