ESRRG
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Official Full Name
estrogen-related receptor gamma -
Overview
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5 end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011] -
Synonyms
ESRRG;estrogen-related receptor gamma;ERR3;NR3B3;ERRgamma;ERR gamma-2;estrogen receptor-related protein 3;nuclear receptor subfamily 3 group B member 3
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
ESRRG involved in several pathways and played different roles in them. We selected most pathways ESRRG participated on our site, such as Gene Expression,Generic Transcription Pathway,Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESRRG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nuclear Receptor transcription pathway | NRBF2,NR6A1A,PPARAA,NRBF2B,NRBP1,NR2F6B,ESR2A,ESR2B,NR1H3,NR4A2B |
| Generic Transcription Pathway | ZNF230,LRPPRC,ZNF79,ZNF302,CDK8,ZNF34,ZNF839,ZIM3,ZNF264,ZNF189 |
| Gene Expression | HNRNPH1,DNMT3L,ZIM2,ZNF71,TSEN54,ESR2B,HNRNPF,SNAPC3,ZNF34,ZNF785 |
Protein Function
ESRRG has several biochemical functions, for example, AF-2 domain binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESRRG itself. We selected most functions ESRRG had, and list some proteins which have the same functions with ESRRG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| steroid hormone receptor activity | RARAA,NR5A1B,NR0B2,THRAA,THRB,PPARD,RORC,PPARG,ESR2A,GPR30 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZNF773,ATF4,TFAP2D,CUX2,H2AFY,ZNF711,ZSCAN20,PHOX2A,ZNF480,MEF2C |
| protein binding | FUZ,ARL16,DIP2A,PIAS4,DNA2,FAM176B,ZSCAN12,TEKT3,DCC,HLCS |
| steroid binding | HSD11B2,PAQR5,FAM84B,PAQR5B,ESRRGA,ESRRA,AKR1D1,ESR2,SERPINA6,ESR2A |
| zinc ion binding | HE2,PARP1,RORC,RNF114,LASP1,PRDM4,CCS,S100A6,PRDM2,MKRN3 |
| AF-2 domain binding | PPARGC1B,NR0B1 |
| retinoic acid receptor activity | RARGA,RARAA,RARAB,NR1D4B,RARB,RARGB,RXRA,RARA,RARG |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | GATA1A,SOHLH2,TRPS1,TP53,OSR2,STAT3,MAFBB,ONECUT3,FOXF2,HIF1A |
Interacting Protein
ESRRG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESRRG here. Most of them are supplied by our site. Hope this information will be useful for your research of ESRRG.
PPARGC1A;SHTN1;MEOX2;g2xkq0_human;NR0B1;CCDC67;NUP160
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References
- Than, NG; Romero, R; et al. Evolutionary origins of the placental expression of chromosome 19 cluster galectins and their complex dysregulation in preeclampsia. PLACENTA 35:855-865(2014).
- Noordmans, GA; Huang, Y; et al. Genetic Analysis of Intracapillary Glomerular Lipoprotein Deposits in Aging Mice. PLOS ONE 9:-(2014).
