ESCO2
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Official Full Name
establishment of cohesion 1 homolog 2 (S. cerevisiae) -
Overview
This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. -
Synonyms
ESCO2;establishment of cohesion 1 homolog 2 (S. cerevisiae);RBS, Roberts syndrome;N-acetyltransferase ESCO2;EFO2;CTF7, S. CEREVISIAE, HOMOLOG OF, 2;ECO1 homolog 2;ECO1, S. CEREVISIAE, HOMOLOG OF, 2;ESO1, S. POMBE, HOMOLOG OF, 2;ESTABLISHMENT FACTOR ORTHOLOG 2;Establishment of cohesion 1 homolog 2;N acetyltransferase ESCO2;RBS;Roberts syndrome;2410004I17Rik
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ESCO2-01H | Recombinant Human ESCO2, GST-tagged | E.coli | Human | GST | 2-352a.a. |
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| ESCO2-1159Z | Recombinant Zebrafish ESCO2 | Mammalian Cells | Zebrafish | His |
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| ESCO2-3497H | Recombinant Human ESCO2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ESCO2-5319M | Recombinant Mouse ESCO2 Protein | Mammalian Cells | Mouse | His |
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| ESCO2-2862M | Recombinant Mouse ESCO2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ESCO2-2862M-B | Recombinant Mouse ESCO2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ESCO2-4699HF | Recombinant Full Length Human ESCO2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 601 amino acids |
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Involved Pathway
ESCO2 involved in several pathways and played different roles in them. We selected most pathways ESCO2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Establishment of Sister Chromatid Cohesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESCO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle, Mitotic | CEP135,NUMA1,MYCA,DULLARD,BANF1,NDC80,LIN54,H3F3D,KIF2A,CKS1B |
| Cell cycle | DBF4,DSN1,TMEM188,MCM5,PLK4,RBL1,KIF2A,TP53BP1,CDC27,E2F5 |
| S Phase | ESCO1,GINS3,GINS1,GINS4,GINS2,MYCA |
| Establishment of Sister Chromatid Cohesion | CDCA5,WAPAL,STAG1,PDS5A,ESCO1,STAG2,PDS5B |
Protein Function
ESCO2 has several biochemical functions, for example, lysine N-acetyltransferase activity, acting on acetyl phosphate as donor,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESCO2 itself. We selected most functions ESCO2 had, and list some proteins which have the same functions with ESCO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lysine N-acetyltransferase activity, acting on acetyl phosphate as donor | CEACAM21,RHBDL1,NAT8,KAT2B,NAT8B,EP300 |
| metal ion binding | NT5C2L1,CDK2,JADE1,NRP1A,EXO1,ZFP82,KLK1B3,ZFP654,ZNF438,PDE4B |
Interacting Protein
ESCO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESCO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESCO2.
Lrrcc1;YEATS4;USF1;S100A4;Bmpr1a;NCAPD3;MATR3;Cct2;Rpl35;Poc1a;CBX8
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References
- Hammerschmidt, K; Whelan, G; et al. Mice lacking the cerebral cortex develop normal song: Insights into the foundations of vocal learning. SCIENTIFIC REPORTS 5:-(2015).
- Rockwell, N; Weech, A; et al. NOVEL CHROMATIN REGULATORY ACTIVITY OF ESCO2 IN CANCER AND NEURAL DEVELOPMENT. NEURO-ONCOLOGY 16:-(2014).
