ERAP1
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Official Full Name
endoplasmic reticulum aminopeptidase 1 -
Overview
ARTS1/Adipocyte-derived leucine aminopeptidase (A-LAP) is a member of the M1 family of zinc metallopeptidases. A-LAP is upregulatable by gamma interferon and trims N-terminal lysine, leucine, tyrosine and asparagines residues when they are not followed by -
Synonyms
ERAP1;endoplasmic reticulum aminopeptidase 1;A LAP;adipocyte derived leucine aminopeptidase;aminopeptidase regulator of TNFR1 shedding;ARTS 1;ERAAP1;KIAA0525;PILS AP;puromycin insensitive leucyl specific aminopeptidase;aminopeptidase PILS;adipo
Recombinant Proteins
- Human
- Rat
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- GST
- His
- Avi
- Fc
- Myc
- DDK
- Flag
Involved Pathway
ERAP1 involved in several pathways and played different roles in them. We selected most pathways ERAP1 participated on our site, such as Adaptive Immune System,Antigen Presentation: Folding, assembly and peptide loading of class I MHC,Class I MHC mediated antigen processing &, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| presentation | ASB14,NPEPPS,ASB18,CD207,RNF182,RNF34,ASB4,ASB13,LRR1,ASB10 |
| Immune System | UBR1,NLRP4B,RNF220,GBP4,TANK,TREX1,PVRL2L,LY86,UBE2F,TRIM62 |
| Adaptive Immune System | RAPGEF4,FGF8B,CLTC,STIM1B,ASB10,CDKN1A,DYNC1LI2,SPTBN2,RNF14,KIF11 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | ERAP2,SEC23A,SEC24A,B2ML |
| Class I MHC mediated antigen processing & | CTSL2,LTN1,UBE2E3,ASB2,DTX3L,CD207,KLHL21,SPSB4,DZIP3,ARIH2 |
Protein Function
ERAP1 has several biochemical functions, for example, aminopeptidase activity,interleukin-1, Type II receptor binding,interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERAP1 itself. We selected most functions ERAP1 had, and list some proteins which have the same functions with ERAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-1, Type II receptor binding | IL1RN |
| metalloaminopeptidase activity | RNPEP,RNPEPL1,XPNPEP1,ANPEPB,ENPEP,METAP2A,Npepo,METAP2B,LTA4H,ERAP2 |
| zinc ion binding | BMP1B,ZDHHC15A,RNF182,KPNB1,KCMF1,TIMM10,PJA2,TRHDE,ADAM10,RBM5 |
| tumor necrosis factor receptor binding | EDA,TNFSF14,TNFSF10L,TNFSF9,TNFSF8,TRAF6,TRAF3,TNFSF10L4,LTB,TNFB |
| protein binding | PKHD1L1,FBN2,MED18,DRD1,AHCY,C3orf52,Artn,DDX39A,RYR1,MEF2C |
| aminopeptidase activity | METAP1D,Ctsl,ERAP2,TRHDE,Npepo,METAP2A,PHEX,METAP1,METAP2,RNPEP |
| metalloexopeptidase activity | METAP2A,LAP3,DPEP3,METAP2B,DPEP1,DPEP2,METAP2,NPEPL1,RNPEP,NUDT16 |
| interleukin-6 receptor binding | PYCARD,CNTF,IL6,ADAM17 |
| peptide binding | IDE,ADNP,HCRTR2,NPFFR1L2,BDKRB1,ANPEPA,CCKAR,NPFFR2.1,OXTRL,GNRHR1 |
Interacting Protein
ERAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERAP1.
IL6R;TNFRSF1A;yapH;1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate
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References
- Smith, JA; et al. Update on Ankylosing Spondylitis: Current Concepts in Pathogenesis. CURRENT ALLERGY AND ASTHMA REPORTS 15:-(2015).
- Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
