EFNA3
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Official Full Name
ephrin-A3 -
Overview
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. -
Synonyms
EFNA3;ephrin-A3;EPLG3;Ehk1 L;LERK3;EFL-2;LERK-3;EHK1 ligand;ligand of eph-related kinase 3;eph-related receptor tyrosine kinase ligand 3;EFL2;Ehk1-L
Recombinant Proteins
- Human
- Mouse
- Human/Cynomolgus
- Rhesus macaque
- HEK293
- Mammalian Cells
- Human
- Wheat Germ
- E.coli
- Human Cells
- In Vitro Cell Free System
- His
- Non
- Fc
- GST
- Avi
Involved Pathway
EFNA3 involved in several pathways and played different roles in them. We selected most pathways EFNA3 participated on our site, such as Axon guidance,Developmental Biology,EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | NOTCH2,TNR,DNMT1,MCL1,ERBB2,MTOR,SHC4,RASSF1,PDCD4,ABL1 |
| Developmental Biology | UNC5D,COL4A4,PSPN,TDGF1,FRS2A,KALRN,KBTBD7,EFNB2A,CCNC,DPYSL5B |
| PI3K-Akt signaling pathway | CSF3R,COMP,CSH,EFNA2,CSH1,PIK3AP1,CDC37,CSF1R,PRP2,LOC608458 |
| EPH-ephrin mediated repulsion of cells | EFNB3B,EFNA5,EFNA1,EFNB1,AP2S1,EFNA2A,EPHA2,EPHB4B,EFNA1A,EFNB2 |
| EPH-Ephrin signaling | MYL9,ARHGEF28,EFNB3,EFNA1A,ACTR2,ARPC5,AP2A2,CLTC,DNM1,KALRN |
| EPHA-mediated growth cone collapse | MYL9,EPHA10,EFNA1B,EFNA2,EFNA2A,EFNA5,MYL12B,EPHA4A,SHB,EFNA3B |
| EPHA forward signaling | ARHGEF15,EPHA2,EFNA2,BLK,EFNA1,CRKL,EFNA5 |
| Axon guidance | CLTA,GNAI2,ARPC1A,LAMTOR2,PTK2,ITGB1,NRG4,PHB,SEMA3C,SEMA4D |
Protein Function
EFNA3 has several biochemical functions, for example, ephrin receptor binding,protein binding,transmembrane-ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNA3 itself. We selected most functions EFNA3 had, and list some proteins which have the same functions with EFNA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LIMS1,TRIM43,ADCYAP1R1,MGAT5B,HAGH,COPS7A,RALBP1,NUTF2,CSTF2T,KCNJ10 |
| transmembrane-ephrin receptor activity | EPHB1,EPHA1,EFNA4,EPHA5,EFNB3,EPHA4,EPHB2,EPHA10 |
| ephrin receptor binding | EFNA5,EFNA3B,EFNB2A,CDK5,EFNA1B,EFNA1,EPHA4,SRC,GRB2,SIPA1L1 |
Interacting Protein
EFNA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNA3.
MEOX2;NOTCH2NL;PRSS23
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