EPHA8
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Official Full Name
EPH receptor A8 -
Overview
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily ty -
Synonyms
EPHA8;EPH receptor A8;EEK, EphA8;ephrin type-A receptor 8;Hek3;EPH-like kinase 3;tyrosylprotein kinase;protein-tyrosine kinase;hydroxyaryl-protein kinase;EPH- and ELK-related kinase;EPH- and ELK-related tyrosine kinase;tyrosine-protein kinase
Recombinant Proteins
- Human
- Mouse
- Mammalian cells
- Mammalian Cell
- Insect Cell
- HEK293
- Sf9 Insect Cell
- Fc
- Non
- His
- GST
- His&Flag
- His&Fc&Avi
Involved Pathway
EPHA8 involved in several pathways and played different roles in them. We selected most pathways EPHA8 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | CNKSR1,ROCK1,SPNA1,HBEGF,KLB,CSNK2A2,SEMA4B,RHOAE,EPHA2A,SHB |
Protein Function
EPHA8 has several biochemical functions, for example, ATP binding,GPI-linked ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHA8 itself. We selected most functions EPHA8 had, and list some proteins which have the same functions with EPHA8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | EHD1,PIK3C2B,GATB,MCM3L,ULK1A,ABCC10,AGK,STK17A,KCNJ1,CARS |
| GPI-linked ephrin receptor activity | EPHA5,EK1,EPHA4,EPHA3,EPHA7 |
Interacting Protein
EPHA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHA8.
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References
- Yan, Y; Wang, Q; et al. miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8. FEBS LETTERS 589:756-765(2015).
- McKinney, N; Yuan, LP; et al. EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma. JOURNAL OF NEURO-ONCOLOGY 121:109-118(2015).
