EN1

  • Official Full Name

    engrailed homeobox 1

  • Overview

    Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the engrailed (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

  • Synonyms

    EN1;engrailed homeobox 1;homeobox protein engrailed-1;hu-En-1;engrailed homolog 1;homeobox protein en-1

Recombinant Proteins

  • Chicken
  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • His&B2M
  • GST
  • His
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
EN1-1199C Recombinant Chicken EN1 Protein, His-B2M-tagged E.coli Chicken His&B2M 1-333 a.a.
EN1-3297H Recombinant Human EN1 Protein, GST-tagged Wheat Germ Human GST
EN1-5191M Recombinant Mouse EN1 Protein Mammalian Cell Mouse His
EN1-2784M Recombinant Mouse EN1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
EN1-2784M-B Recombinant Mouse EN1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
EN1-2963H Recombinant Human EN1 Protein (Met1-Glu392), C-His tagged E.coli Human His Met1-Glu392
EN1-301198H Recombinant Human EN1 protein, GST-tagged E.coli Human GST Met109-Asn197
EN1-4285HF Recombinant Full Length Human EN1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 392 amino acids

    Involved Pathway

    EN1 involved in several pathways and played different roles in them. We selected most pathways EN1 participated on our site, such as Dopminergic Neurogenesis,SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dopminergic Neurogenesis EN2
    SIDS Susceptibility Pathways SST,ASCL1,CDCA7L,PLP1,CC2D1A,MAZ,SCN3B,DLX2,KCNQ1,TAC1

    Protein Function

    EN1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EN1 itself. We selected most functions EN1 had, and list some proteins which have the same functions with EN1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding GPI1,CETN3,PUS7L,GNG12,MUL1,PPIL2,FAM151B,KRT33B,ATP7A,RITA1
    DNA binding HOXD9A,ZNF558,ATM,PGR,SFPI1,TTC5,EOMESB,BTBD11A,HER4.2,ZNF230
    sequence-specific DNA binding GATA5,EVX2,SMAD3A,TLX2,TBX5,ALX3,IRX1B,FOXQ1A,IRX6,DLX6
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding CUX2,KCNIP3,NKX6-2,MZF1,POU4F2,MYPOP,TBX15,BHLHE40,ATF7,GZF1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZNF253,AKNA,SREBF1,NR1H2,POU4F3,NFKB2,YBX1,RELA,MYF5,MYBL2

    Interacting Protein

    EN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EN1.

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