ELP4
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Official Full Name
elongation protein 4 homolog -
Overview
Elongation protein 4 homolog (ELP4) is a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. Alternative names for ELP4 include elongator co -
Synonyms
ELP4;elongation protein 4 homolog (S. cerevisiae);C11orf19, chromosome 11 open reading frame 19;elongator complex protein 4;PAXNEB;hELP4;PAX6 neighbor gene protein;PAX6NEB;C11orf19;dJ68P15A.1;FLJ20498
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ELP4 involved in several pathways and played different roles in them. We selected most pathways ELP4 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | ASH2L,SMYD2,ACTL6A,MTA2,KDM2AA,ENY2,SMARCD3B,ATXN7L3,ARID4A,EED |
| HATs acetylate histones | CCDC101,PAX3A,ENY2,MORF4L1,TAF6L,MSL2,SAP130,EPC1,ING4,ATXN7 |
| Chromatin modifying enzymes | PRMT5,KDM5BB,DMAP1,AEBP2,SAP18,MBD3B,PRMT6,KDM5D,CAPNS2,KDM5A |
Protein Function
ELP4 has several biochemical functions, for example, contributes_to RNA polymerase II core binding,contributes_to histone acetyltransferase activity,phosphorylase kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ELP4 itself. We selected most functions ELP4 had, and list some proteins which have the same functions with ELP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to histone acetyltransferase activity | TADA1,ING3,TAF10,TAF5L,TAF6L,KAT2A,SUPT7L,TEX30,TADA2A,SUPT3H |
| protein binding | NAPB,SERINC1,RNF182,DOCK1,NAPA,GATA3,PIBF1,CLOCKB,ID2,IWS1 |
| contributes_to RNA polymerase II core binding | IKBKAP,ELP2,ELP3 |
| phosphorylase kinase regulator activity | ELP3,PRKAG2,IKBKAP |
Interacting Protein
ELP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELP4.
IKBKAP;ELP5;CBX6;ELP6;ELP2;ELP3
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References
- Hughes, LA; Gaston, J; et al. Electrospun fiber constructs for vocal fold tissue engineering: Effects of alignment and elastomeric polypeptide coating. ACTA BIOMATERIALIA 13:111-120(2015).
- Gkampeta, A; Fidani, L; et al. Association of brain-derived neurotrophic factor (BDNF) and elongator protein complex 4 (ELP4) polymorphisms with benign epilepsy with centrotemporal spikes in a Greek population. EPILEPSY RESEARCH 108:1734-1739(2014).
