EIF5B
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Official Full Name
eukaryotic translation initiation factor 5B -
Overview
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. -
Synonyms
EIF5B;eukaryotic translation initiation factor 5B;DKFZp434I036;FLJ10524;IF2;KIAA0741;translation initiation factor IF2;eIF 5B;eIF-5B;IF2P_HUMAN;Translation initiation factor IF 2;Translation initiation factor IF-2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
EIF5B involved in several pathways and played different roles in them. We selected most pathways EIF5B participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | NDC1,NXF2,PAIP1,SUMO3A,MAGOHB,NUP205,EIF4BA,SNUPN,RANGAP1A,PABPC4 |
Protein Function
EIF5B has several biochemical functions, for example, GTP binding,GTPase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF5B itself. We selected most functions EIF5B had, and list some proteins which have the same functions with EIF5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | NCL,ZFP326,DHX33,CTNNA1,ANXA7,SF3B2,DUSP11,Txn1,PKM2,PTCD1 |
| GTP binding | RHOF,RAB7,EEF1A1A,MXB,RAB37,RAB8B,ARL5B,RHOBTB1,RRAGCA,GUF1 |
| protein binding | NTF4,SPCS1,R3HDM2,THOC5,CYGB,PPARA,SEC24D,RSL24D1,CANX,CTSH |
| translation initiation factor activity | EIF2S1B,EIF3EA,EIF3JA,EIF4E3,EIF1,EIF3HB,EIF3F,EIF3EB,EIF4A2,EIF4BB |
| GTPase activity | EEF1A2,GTPBP5,RAB33B,RAB42,ATL2,RAB28,DNM2B,ARF4,MRAS,TUBA2 |
Interacting Protein
EIF5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF5B here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF5B.
ETS1;EIF1AY;CSNK2A1;NR3C1;PRKAA1;SMAD2;NELL1;PIH1D1;ssrna_ag;MAPK13;XRCC3;FN1;Eif3a;HDGF;CBX1;SNW1;BECN1
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References
- Pan, YF; Li, QF; et al. Genes associated with thermosensitive genic male sterility in rice identified by comparative expression profiling. BMC GENOMICS 15:-(2014).
- Lee, S; Truesdell, SS; et al. Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E4315-E4322(2014).
