EIF4EBP2
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Official Full Name
eukaryotic translation initiation factor 4E binding protein 2 -
Overview
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent trans -
Synonyms
EIF4EBP2;eukaryotic translation initiation factor 4E binding protein 2;eukaryotic translation initiation factor 4E-binding protein 2;4E-BP2;eIF4E-binding protein 2;phosphorylated, heat and acid stable regulated by insulin protein II;4EBP2;PHASII
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Mouse
- Mammalian Cells
- E.coli
- Wheat Germ
- Human
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
EIF4EBP2 involved in several pathways and played different roles in them. We selected most pathways EIF4EBP2 participated on our site, such as RNA transport,Translation Factors, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4EBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Translation Factors | EIF5A,EIF1,EEF1B2,EEF1D,EEF1A2,EEF2B,EIF2B1,PAIP1,EEF1G |
| RNA transport | PAIP1,SMN2,NMD3,EIF3S10,MAGOH,TACC3,SEH1L,POP7,MAGOHB,XPOT |
Protein Function
EIF4EBP2 has several biochemical functions, for example, eukaryotic initiation factor 4E binding,protein binding,translation repressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4EBP2 itself. We selected most functions EIF4EBP2 had, and list some proteins which have the same functions with EIF4EBP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| eukaryotic initiation factor 4E binding | ANGEL1,EIF4G1,GRA,EIF4EBP3L,EIF4EBP3,LARP1,DDX3X,HHEX,OTX2,EIF4EBP1 |
| translation repressor activity | SAMD4,SAMD4A,CIRBP,IREB2,EIF4EBP1,EIF4EBP3,PAIP2,PATL2,TRIM71 |
| protein binding | ITGB1BP2,WDR24,CYP4F2,GPR77,KIAA1279,TUSC2,FGD2,RPS3,CCBL1,SMC6 |
Interacting Protein
EIF4EBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4EBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4EBP2.
EIF4E;Eif4e2;glmU
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References
- Wang, ZS; Ma, XH; et al. Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 94:1243-1253(2012).
- Rider, MH; Hussain, N; et al. Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of rapamycin signalling pathways. MOLECULAR AND CELLULAR BIOCHEMISTRY 332:207-213(2009).
