EIF4E2
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Official Full Name
eukaryotic translation initiation factor 4E family member 2 -
Overview
Eukaryotic initiation factor 4E (eIF4E) binds to the mRNA cap structure to mediate the initiation of translation (1,2). eIF4E interacts with eIF4G, a scaffold protein that promotes assembly of eIF4E and eIF4A into the eIF4F complex (2). eIF4B is thought t -
Synonyms
EIF4E2;eukaryotic translation initiation factor 4E family member 2;EIF4EL3, eukaryotic translation initiation factor 4E like 3;eukaryotic translation initiation factor 4E type 2;4EHP;IF4e;eIF4E type 2;eIF-4E type 2;eIF4E-like protein 4E-LP;mRNA
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
EIF4E2 involved in several pathways and played different roles in them. We selected most pathways EIF4E2 participated on our site, such as RNA transport,HIF- signaling pathway,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4E2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | RPP25,SUMO4,NUP205,SENP2,NCBP1,NUP133,EIF1,POM121L2,FXR2,UBE2IA |
| PIK-Akt signaling pathway | ATF4,ANGPT4,VWF,RPS6,LAMC1,IFNB1,IL6,VEGFB,YWHAG,PDGFRB |
| mTOR signaling pathway | AKT1S1,STK11,RICTOR,PIK3R3A,RPS6,RPS6KA3A,STRADA,RRAGCB,DDIT4,HIF1AB |
| HIF- signaling pathway | PIK3R3,IGF1R,MTOR,NOS3,LDHA,HK1,SERPINE1,RPS6KB2,Trf,CAMK2B |
| Insulin signaling pathway | NRAS,PDPK1B,FBP1B,G6PC3,FLOT2B,PHKB,FOXO1,PHKG1B,HK2,PDPK1 |
Protein Function
EIF4E2 has several biochemical functions, for example, RNA cap binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4E2 itself. We selected most functions EIF4E2 had, and list some proteins which have the same functions with EIF4E2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EPB41L1,COG8,LRRFIP2,ASNS,PSMB3,SUDS3,PAX5,WBP2NL,TMEM147,DDB2 |
| ubiquitin protein ligase binding | OTUB1,TRAF2,AXIN2,CUL9,RPA3,NLK,SCN5A,FBXW7,WASH1,PRKAR1A |
| RNA cap binding | LARP1,EIF4E,EIF4G3,SNUPN,NCBP1,EIF4A1,NCBP2 |
| translation initiation factor activity | EIF3EB,EIF3BA,EIF2A,EIF6,GTPBP1L,EIF1AY,EIF3S6IP,EIF2S1A,EIF2B5,EIF2S1 |
| poly(A) RNA binding | DIAP1,CS,RPS4Y2,SRP14,CSDA,ZNF207,RBM4B,ZC3H18,HNRNPAB,LUC7L2 |
| translation factor activity, RNA binding | EEF2K,EIF4A1,EIF4G3,CPEB4,CPEB1,EIF1,SOX11,EIF4G1,CPEB1B,ABCF1 |
Interacting Protein
EIF4E2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4E2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4E2.
EIF4ENIF1;KRT13;NECAB2;SPRY2;TADA2A;KRT19;TRIM27
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