EIF2C3
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Official Full Name
eukaryotic translation initiation factor 2C, 3 -
Overview
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded;protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in;short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely;related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript;variants encoding distinct isoforms have been identified for this gene. -
Synonyms
EIF2C3;eukaryotic translation initiation factor 2C, 3;protein argonaute-3;5730550L01Rik;Ago 3;Ago3;AGO3_HUMAN;Argonaute3;eIF 2C 3;eIF-2C 3;eIF2C 3;EIF2C3 protein;Eukaryotic translation initiation factor 2C 3;Eukaryotic translation initiation factor 2C3;FLJ12765;hAgo3;MGC86946;mAgo3;argonaute 3;Piwi/Argonaute family protein meIF2C3;AW048688;C130014L07Rik
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- Mammalian Cell
- Insect Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EIF2C3-3166H | Recombinant Human EIF2C3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EIF2C3-5085M | Recombinant Mouse EIF2C3 Protein | Mammalian Cell | Mouse | His |
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| EIF2C3-5174H | Recombinant Human EIF2C3 protein(Met1-Ala860), His-tagged | Insect Cells | Human | His | Met1-Ala860 |
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| EIF2C3-6666HCL | Recombinant Human EIF2C3 293 Cell Lysate | HEK293 | Human | Non |
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| EIF2C3-2704M | Recombinant Mouse EIF2C3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EIF2C3-2704M-B | Recombinant Mouse EIF2C3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EIF2C3-4571HF | Recombinant Full Length Human EIF2C3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 626 amino acids |
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Involved Pathway
EIF2C3 involved in several pathways and played different roles in them. We selected most pathways EIF2C3 participated on our site, such as Gene Expression,Gene Silencing by RNA,Post-transcriptional silencing by small RNAs, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Post-transcriptional silencing by small RNAs | AGO3B,TNRC6B |
| Gene Silencing by RNA | IPO8,ASZ1,PLD6,TNRC6B,AGO3B,MAEL,MYBL1,BARHL1,FKBP6,TARBP2 |
| Gene Expression | NR6A1A,HNRNPA0,PHF19,CHD4,ZNF664,ZNF2,ZNF124,MTA1,ZNF561,SNAPC5 |
Protein Function
EIF2C3 has several biochemical functions, for example, RNA binding,double-stranded RNA binding,miRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2C3 itself. We selected most functions EIF2C3 had, and list some proteins which have the same functions with EIF2C3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded RNA binding | STAU2,IFIH1,DDX58,TUBA1B,RFTN1,ZFP346,HSPD1,DROSHA,SUPV3L1,TFRC |
| RNA binding | PPP1R8,CDKN2AIP,BAZ2A,RBM20,ATXN1L,NSUN3,RAVER1,TRDMT1,RNMTL1B,IFIT14 |
| nucleic acid binding | TSEN2,KHDRBS1A,OVOL3,HNRNPA1A,RREB1,ZFP536,RNASE6,RNASEH1,TARDBPL,ZFP260 |
| single-stranded RNA binding | DHX58,HNRNPA1,PIWIL1,CBX6,CBX4,JMJD6,ZFP36,IFIT5,TLR8,IFIH1 |
| miRNA binding | MEF2C,AGO4,TARBP2,DICER1,AGO2,AGO1,TRIM71,SOX2,LIN28A,AGO3 |
| poly(A) RNA binding | LSM8,NOVA2,CANX,HNRNPH1,APEH,FBL,HELZ,SNTB2,NKAP,PRPF31 |
Interacting Protein
EIF2C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2C3.
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