EIF2B5
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Official Full Name
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -
Overview
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009] -
Synonyms
EIF2B5;eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa;CLE;CACH;LVWM;EIF-2B;EIF2Bepsilon;translation initiation factor eIF-2B subunit epsilon;eIF-2B GDP-GTP exchange factor subunit epsilon
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
EIF2B5 involved in several pathways and played different roles in them. We selected most pathways EIF2B5 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EIF4G1A,EIF2B3,EIF3B,RPP25,UPF1,NUP88,XPO5,EIF4A3,RPP14,STRAP |
Protein Function
EIF2B5 has several biochemical functions, for example, contributes_to guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B5 itself. We selected most functions EIF2B5 had, and list some proteins which have the same functions with EIF2B5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CNKSR1,CNIH4,OSR2,ENDOG,MRPL27,TMEM182,UBTD1,DDX58,AEBP2,TF |
| translation initiation factor binding | LIN28A,LARP1,RPS24,EIF2B4,EIF2B3,CELF1,EIF3C,EIF3B,EIF3F,EIF3M |
| contributes_to translation initiation factor activity | EIF3D,EIF2B1,EIF3HA,EIF3K,EIF3I,EIF2B3,EIF2B2,EIF3B,EIF3M,EIF3A |
| contributes_to guanyl-nucleotide exchange factor activity | C7orf59,ALS2,EIF2B2,EIF2B4,LAMTOR3,EIF2B3,LAMTOR1,EIF2B1,HBXIP,LAMTOR2 |
| translation initiation factor activity | EIF4E2,EIF3EA,EIF3J,EIF4A2,AGO2,EIF3S10,MTIF2,EIF3E,EIF6,EIF4H |
| guanyl-nucleotide exchange factor activity | TIAM2,ARHGEF39,DOCK1,GAPVD1,FGD4,ARHGEF11,TBC1D10A,FGD6,RASGEF1C,FGD3 |
Interacting Protein
EIF2B5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B5 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B5.
pi3p;NSS
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References
- Yang, S; Zhang, H; et al. Reconstructing the coding and non-coding RNA regulatory networks of miRNAs and mRNAs in breast cancer. GENE 548:6-13(2014).
- Zahoor, I; Hamid, Z; et al. Novel mutations identified in EIF2B5 gene in Kashmiri patients as susceptibility factor for multiple sclerosis. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 51:115-120(2014).
