EIF2A
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Official Full Name
eukaryotic translation initiation factor 2A, 65kDa -
Overview
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al.,;2002 (PubMed 12133843)). -
Synonyms
EIF2A;eukaryotic translation initiation factor 2A, 65kDa;eukaryotic translation initiation factor 2A;EIF 2A;65 kDa eukaryotic translation initiation factor 2A;CDA02;EIF-2A;MST089;MSTP004;MSTP089
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- GST
- Non
- His
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
EIF2A involved in several pathways and played different roles in them. We selected most pathways EIF2A participated on our site, such as IL-6 Signaling Pathway,TGF-beta receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta receptor signaling | STRAP,DAB2,TGFBR3 |
| IL-6 Signaling Pathway | BMX,CDK5R1B,DAXX |
Protein Function
EIF2A has several biochemical functions, for example, protein binding,ribosome binding,tRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2A itself. We selected most functions EIF2A had, and list some proteins which have the same functions with EIF2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tRNA binding | IFIT5,FARSA,YARS2,SEPSECS,RARS,SSB,CTU1,AIMP1,CTU2,PTCD1 |
| translation initiation factor activity | EIF4H,EIF4E3,EIF1,EIF4E2,EIF3S10,EIF4G2,EIF1AXA,DENR,EIF4EA,EIF4G3 |
| ribosome binding | OLA1,ETF1,HSPA5,CPEB1A,RICTOR,ERI1,WIBG,CPEB3,EIF5A,EIF3K |
| protein binding | SEC14L4,CCNB3,H2AFY,KIF7,COG3,VPS37A,LPL,EMX2,MEX3C,KCNJ9 |
Interacting Protein
EIF2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2A here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2A.
MLH1;q81z87_bacan;MAST3;ABL1;NEDD8;ESR2;UPF1
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References
- Dametto, P; Lakkaraju, AKK; et al. Neurodegeneration and Unfolded-Protein Response in Mice Expressing a Membrane-Tethered Flexible Tail of PrP. PLOS ONE 10:-(2015).
- Wu, CX; Wang, SJ; et al. The Z alpha domain of PKZ from Carassius auratus can bind to d(GC)(n) in negative supercoils. FISH & SHELLFISH IMMUNOLOGY 28:783-788(2010).
