EGLN1
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Official Full Name
egl-9 family hypoxia-inducible factor 1 -
Overview
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009] -
Synonyms
EGLN1;egl-9 family hypoxia-inducible factor 1;HPH2;PHD2;SM20;ECYT3;HPH-2;HIFPH2;ZMYND6;C1orf12;HIF-PH2;egl nine homolog 1;egl nine-like protein 1;HIF prolyl hydroxylase 2;HIF-prolyl hydroxylase 2;zinc finger MYND domain-containing protein 6;hypoxia-inducible factor prolyl hydroxylase 2;prolyl hydroxylase domain-containing protein 2
Recombinant Proteins
- Human
- Mouse
- E.coli
- Insect cells
- Wheat Germ
- HEK293
- Mammalian Cell
- E. coli
- Mamanlian cells
- HEK293T
- GST
- FLAG
- Myc&DDK
- His
- Non
- Flag
- His&Fc&Avi
- His&Myc
Involved Pathway
EGLN1 involved in several pathways and played different roles in them. We selected most pathways EGLN1 participated on our site, such as HIF- signaling pathway,Pathways in cancer,Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | RBX1,PRKCB,IL6,GM5506,RELA,HMOX1,EPO,TCEB1,PFKFB3,PRKCA |
| Renal cell carcinoma | PAK2,PIK3R3,VEGFA,PAK3,RAF1,TGFB3,MAP2K1,GAB1,GRB2,PAK1 |
| Pathways in cancer | XIAP,WNT1,BDKRB1,WNT10B,PTCH2,TGFBR1,LAMA1,ZBTB16,PRKACG,RELA |
Protein Function
EGLN1 has several biochemical functions, for example, L-ascorbic acid binding,enzyme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGLN1 itself. We selected most functions EGLN1 had, and list some proteins which have the same functions with EGLN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | CYP2C37,IRGM1,CYP4A12A,CYP7A1A,ETHE1,CYP4F14,CYP2X10.2,PHF2,CYP3A25,CYP46A1.2 |
| peptidyl-proline dioxygenase activity | OGFOD1 |
| enzyme binding | C6orf211,SLC27A2,PRKDC,CYB5A,NOTCH1,ANK1,MSH3,SCNM1,NFKBIA,ADORA2A |
| L-ascorbic acid binding | PLOD3,LEPREL1,EGLN1B,EGLN3,P4HTM,OGFOD2,TMLHE,LEPREL2,P4HA1,EGLN2 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | KDM5C,JHDM1D,EGLN2,EGLN3,KDM5D,C14orf169,KDM5B,KDM5BB,ALKBH5,HIF1AN |
| peptidyl-proline 4-dioxygenase activity | EGLN2,EGLN3 |
| protein binding | TRIM5,UGGT1,KDM1A,EPCAM,FCRL4,VPS72,AP2S1,SCAND1,WDR18,IFI30 |
Interacting Protein
EGLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGLN1.
HIF1A;FKBP8;EPAS1;OS9;PKM
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