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EFS

Official Full Name

embryonal Fyn-associated substrate
Overview

The protein encoded by this gene contains a SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to be able to bind to SH3 domain of protein-tyrosine kinases. The function of this gene is unknown. Two alternatively spliced variants have been described.
Synonyms

EFS; embryonal Fyn-associated substrate; Cas scaffolding protein family member 3; CASS3; EFS1; EFS2; HEFS; SIN; CAS3; Embryonal Fyn associated substrate; signal transduction protein (SH3 containing);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EFS-3108H	Recombinant Human EFS Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EFS-6699HCL	Recombinant Human EFS 293 Cell Lysate	HEK293	Non		Inquiry
Human	EFS-3849H	Recombinant Human EFS Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	EFS-4238HF	Recombinant Full Length Human EFS Protein, GST-tagged	In Vitro Cell Free System	GST	468 amino acids	Inquiry
Mouse	EFS-5038M	Recombinant Mouse EFS Protein	Mammalian Cell	His		Inquiry
Mouse	EFS-2673M-B	Recombinant Mouse EFS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Efs-2757M	Recombinant Mouse Efs Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	EFS-2673M	Recombinant Mouse EFS Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

EFS involved in several pathways and played different roles in them. We selected most pathways EFS participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EFS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

EFS has several biochemical functions, for example, SH3 domain binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EFS itself. We selected most functions EFS had, and list some proteins which have the same functions with EFS. You can find most of the proteins on our site.

Function	Related Protein
SH3 domain binding	WIPF3;SHANK3;ABI2;VASP;DENND1A;DNM2;CYBA;PLSCR3;SH3BP5LA
protein binding	LARP4B;SIRPB1;SART3;RIC8A;PDIA3;LILRB3;RAN;BRCA1;PLK3
protein domain specific binding	RAP2B;TWIST1;STMN3;NR0B2;MITD1;IPCEF1;TRIM11;PPARA;HIST4H4

EFS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFS here. Most of them are supplied by our site. Hope this information will be useful for your research of EFS.

NUP155; SORBS2; FYN; ZNF417; OSTF1; TSSK1B; ABI2

Research Area

Ramani, P; Nash, R; et al. Aurora kinase A is superior to Ki67 as a prognostic indicator of survival in neuroblastoma. HISTOPATHOLOGY 66:370-379(2015).

Coquenlorge, S; Duchalais, E; et al. Modulation of lipopolysaccharide-induced neuronal response by activation of the enteric nervous system. JOURNAL OF NEUROINFLAMMATION 11:-(2014).