ECM1
-
Official Full Name
extracellular matrix protein 1 -
Overview
This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. -
Synonyms
ECM1;extracellular matrix protein 1;secretory component p85
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cells
- Wheat Germ
- Human Cells
- In Vitro Cell Free System
- GST
- His
- Non
- Flag
- Avi&Fc&His
- DDK&Myc
- GST&His
Involved Pathway
ECM1 involved in several pathways and played different roles in them. We selected most pathways ECM1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ECM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ECM1 has several biochemical functions, for example, enzyme binding,interleukin-2 receptor binding,laminin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ECM1 itself. We selected most functions ECM1 had, and list some proteins which have the same functions with ECM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| laminin binding | GPC1,ITGA9,ITGA3,PLEKHA2,LYPD5,BCAM,ADAM9,NCL,AGRN,LGALS3 |
| protease binding | THAP5,ADAMTS4,ALPI,Casp3,IL1R1,SERPINA1E,BRCA2,SERPINB6,FURIN,RFFL |
| protein binding | KRTAP19-7,MTMR9,FAM46B,LRRC75A-AS1,MASP2,CLDN8,CD63,TRIM10,PTMA,MPP2 |
| protein C-terminus binding | ITGB3BP,NEIL1,NCL,KCNK3,RBFOX1,ERCC2,PHB,CSK,MED12,GRIP1 |
| interleukin-2 receptor binding | Il2,IL21,TIMM50,GATA3 |
| enzyme binding | RFC5,CTNNBL1,NFKBIA,HSPA6,HSPA1B,MAP2K7,LDB1,GOT2,PEX5,TBP |
| signal transducer activity | OLFR146,TRIM54,DRD2B,OLFR958,GNGT1,OLFR495,TAAR14F,IL15RA,OLFCG4,HTR5AL |
Interacting Protein
ECM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECM1.
SRPK1;BNIP3L;ATN1;pyrF;CPTP;q7arb3_yerpe;q7ckb2_yerpe;q8ckn0_yerpe;RERE;IRAK3
Resources
Research Area
Extracellular Matrix MoleculesMetalloproteases and Regulators
Other ECM Glycoproteins
Related Services
Related Products
References
- Lee, KM; Nam, K; et al. Extracellular matrix protein 1 regulates cell proliferation and trastuzumab resistance through activation of epidermal growth factor signaling. BREAST CANCER RESEARCH 16:-(2014).
- Plevy, S; Silverberg, MS; et al. Combined Serological, Genetic, and Inflammatory Markers Differentiate Non-IBD, Crohn's Disease, and Ulcerative Colitis Patients. INFLAMMATORY BOWEL DISEASES 19:1139-1148(2013).
