EBF1
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Official Full Name
early B-cell factor 1 -
Overview
Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. -
Synonyms
EBF1;early B-cell factor 1;early B cell factor , EBF;transcription factor COE1;OLF1;COE1;Early B cell factor 1;EBF;O/E 1;OE-1;OTTHUMP00000160817;OTTHUMP00000224200;OTTHUMP00000224217;olfactory neuronal transcription factor 1;Collier, Olf and EBF transcription factor 1;O/E-1
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
EBF1 involved in several pathways and played different roles in them. We selected most pathways EBF1 participated on our site, such as Adipogenesis,Developmental Biology,Transcriptional regulation of white adipocyte differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EBF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | SMAD3B,CDKN1A,HMGA1,NRIP1,NR1H3,KLF6A,CYP26A1,NR2F1A,PIANP,MEF2B |
| Developmental Biology | CEBPA,EFNA2A,CACNG2B,SCN3A,CCNC,PEA15,RHOAE,RASGRP1,RHOB,EFNA5 |
| Transcriptional regulation of white adipocyte differentiation | MED9,MED19,CDK19,MED22,MED29,MED21,EGR2,MED18,NR2F2 |
Protein Function
EBF1 has several biochemical functions, for example, C2H2 zinc finger domain binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EBF1 itself. We selected most functions EBF1 had, and list some proteins which have the same functions with EBF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | JAZF1B,PLAGL1,CYP2AA6,NPEPPS,SMPD4,ZNF79,NT5C3L,LHX1B,ZBTB20,KLF6A |
| C2H2 zinc finger domain binding | U2AF2,GATA2,EHMT2,GATA1,WT1,EHMT1,ZXDC,THAP7,HMGA2,TAF9 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | HOXD13,ALS2CR8,FOSL1,GABPA,POU3F2,PITX3,SIX2,NR6A1,RAX,SRF |
| protein binding | SIK2,ELANE,MBP,GNB1,BFSP2,BMPR1B,LRPAP1,ZNF625,MCL1,POLR1A |
| protein dimerization activity | NUP210,MYCA,ABCG1,TFE3,BHLHE41,HES6,HES4,SCXB,MESPAA,MYCB |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GATA1,NR2E1,TLX1,MAFB,PLAG1,RELA,NFKB2,DBP,ESRRA,SOX2 |
Interacting Protein
EBF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EBF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EBF1.
HOMEZ;ATPAF2;BCL6
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References
- Zwollo, P; Ray, JC; et al. B cell signatures of BCWD-resistant and susceptible lines of rainbow trout: A shift towards more EBF-expressing progenitors and fewer mature B cells in resistant animals. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:1-12(2015).
- Itoh-Nakadai, A; Hikota, R; et al. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program. NATURE IMMUNOLOGY 15:1171-1180(2014).
