E4F1

  • Official Full Name

    E4F transcription factor 1

  • Overview

    The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.

  • Synonyms

    E4F1;E4F transcription factor 1;transcription factor E4F1;E4F;E4F transcription factor 1, isoform CRA_b;P120E4F transcription factor;p50E4F;p120E4F;transcription factor E4F;putative E3 ubiquitin-protein ligase E4F1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
E4F1-3019H Recombinant Human E4F1 protein, His-tagged E.coli Human His 436-784 aa
E4F1-1369R Recombinant Rhesus monkey E4F1 Protein, His-tagged Mammalian Cells Rhesus macaque His
E4F1-27377TH Recombinant Human E4F1, His-tagged E.coli Human His 137-588 a.a.
E4F1-3011H Recombinant Human E4F1 Protein, GST-tagged Wheat Germ Human GST
E4F1-3132Z Recombinant Zebrafish E4F1 Mammalian Cells Zebrafish His
E4F1-4938M Recombinant Mouse E4F1 Protein Mammalian Cells Mouse His
E4F1-522HCL Recombinant Human E4F1 cell lysate Human Non
E4F1-1194R Recombinant Rhesus Macaque E4F1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
E4F1-1194R-B Recombinant Rhesus Macaque E4F1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
E4F1-2602M Recombinant Mouse E4F1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
E4F1-2602M-B Recombinant Mouse E4F1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
E4F1-4117HF Recombinant Full Length Human E4F1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 784 amino acids

    Involved Pathway

    E4F1 involved in several pathways and played different roles in them. We selected most pathways E4F1 participated on our site, such as p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with E4F1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    p53 pathway CSE1L,SMYD2,PPP1R13L,CSNK1G3,TRIM28,TTC5,HUWE1,FBXO11,DYRK2,NEDD8

    Protein Function

    E4F1 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,cAMP response element binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E4F1 itself. We selected most functions E4F1 had, and list some proteins which have the same functions with E4F1. You can find most of the proteins on our site.

    Function Related Protein
    transcription coactivator activity RBPMS,NCOA2,PER2,SRA1,ATF2,GATA3,SMARCB1,JUPA,RXRB,SMARCE1
    metal ion binding ZFP667,TDP2B,HBAE3,HDAC9,ZFP771,SGSH,SP9,PDXK,ATP13A3,RC3H2
    transcription corepressor activity YAP1,CDYL,DDIT3,DAXX,CBX4,HDAC9,DNMT3B,AJUBA,MNT,SAP30
    DNA binding TOX2,POU6F1,POU3F3B,SOX21,ZNF143,SETBP1,MEIS4.1A,ZBED4,SAP30,BACH1A
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding MITF,FEZF2,ISX,VAX2,ARHGAP35,ARID5B,POU5F1,CHCHD3,ESX1,VAX1
    cAMP response element binding CREB3L4,CREB3L3L,ATF6B,CREB3,CREB3L3A,CREB3L1,ATF2,CREB3L2,JUN,CREB3L3
    RNA polymerase II regulatory region sequence-specific DNA binding XBP1,DMRT1,NHLH1,FOXF1,KAT2B,HSF2,TFAP2E,EAF2,GATA5,BCL6AB
    ligase activity RNF126,TRAF2,MARCH9,RNF181,HERC4,RNF38,RNF220,ZNRF3,RNF187,MARCH1
    transcription factor activity, sequence-specific DNA binding HIST1H2AH,ZRANB2,FOXD1L,DMRT3,PHOX2A,TBR1B,LZTS1,POU1F1,ZIC3,SIX1B

    Interacting Protein

    E4F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E4F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of E4F1.

    RASSF1;gam1_adeg1;ANP32A;lnx2b;X

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