DYRK3
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Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -
Overview
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
DYRK3;dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3;dual specificity tyrosine-phosphorylation-regulated kinase 3;dual specificity tyrosine (Y) phosphorylation regulated kinase 5;hYAK3 2;protein kinase Dyrk3;RED;REDK;regulatory e
Recombinant Proteins
- Rat
- Human
- Cynomolgus
- Mammalian Cell
- Insect Cell
- Wheat Germ
- Insect Cells
- HEK293
- In Vitro Cell Free System
- Insect (sf21)
- His
- GST
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
DYRK3 involved in several pathways and played different roles in them. We selected most pathways DYRK3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DYRK3 has several biochemical functions, for example, ATP binding,magnesium ion binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK3 itself. We selected most functions DYRK3 had, and list some proteins which have the same functions with DYRK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PTK2B,SNRKB,ALPK1,CDK7,RAF1,MASTL,UBE2J2,ATP1A2A,PIF1,DNAJA3A |
| magnesium ion binding | ALPP,PRPS1,TSSK4,PKM,ATP4A,ENO4,PPM1BB,PRKACB,ENO1B,THG1L |
| protein serine/threonine kinase activity | DSTYK,ACVR2A,RPS6KB2,TBK1,MAPKAPK2,NEK12,STK36,CLK2,PAK4,MTOR |
| protein serine/threonine/tyrosine kinase activity | RPS6KA2,ACVR2B,DYRK2,PRKCG,CLK1,MAP2K1,DYRK1A,CLK4,TNK2,PRKACA |
| protein kinase activity | CAMKV,PRKDC,EK1,BMPR1AB,IRAK1,ULK1A,CAMK2B1,PRKACBB,NRBP1,RPS6KA3 |
| protein tyrosine kinase activity | MAP2K2,ERBB2,FER,MAP3K9,DYRK4,CSK,FGFR1A,PTK2AB,CSF1RA,EPHA4B |
Interacting Protein
DYRK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK3.
saicar;PRNP;PKM;SORL1;SIRT1
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References
- Souchet, B; Latour, A; et al. Molecular Rescue of DYRK1A Overexpression in Cystathionine Beta Synthase-Deficient Mouse Brain by Enriched Environment Combined with Voluntary Exercise. JOURNAL OF MOLECULAR NEUROSCIENCE 55:318-323(2015).
- Mennenga, SE; Gerson, JE; et al. Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing. PHYSIOLOGY & BEHAVIOR 138:260-265(2015).
