DYRK2
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Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 -
Overview
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or;development. The family is defined by structural similarity of their kinase domains and their capability to;autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed;phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform,;isoform 1, lacks a 5 terminal insert. -
Synonyms
DYRK2;dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2;dual specificity tyrosine-phosphorylation-regulated kinase 2;FLJ21217;FLJ21365
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Insect Cell
- Wheat Germ
- Sf9 Insect Cell
- HEK293
- Insect (sf21)
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
DYRK2 involved in several pathways and played different roles in them. We selected most pathways DYRK2 participated on our site, such as p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p53 pathway | KAT8,TRIM28,FBXO11,CSE1L,NEDD8,HUWE1,RASSF1,E4F1,TTC5,SMYD2 |
Protein Function
DYRK2 has several biochemical functions, for example, ATP binding,magnesium ion binding,manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK2 itself. We selected most functions DYRK2 had, and list some proteins which have the same functions with DYRK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| magnesium ion binding | ATP9A,PKM2,BPNT1,ADSSL1,ENO3,PGM1,ATP8B5,PRPS1B,ENO1A,TSSK3 |
| ATP binding | KSR2,CDKL4,TNK2,CAMK1GB,DYRK4,MAP3K10,DDX31,KIF12,OASL2,NVL |
| manganese ion binding | MTPAP,DCP2,GALNT3,XPNPEP1,ENDOU,TDP2,ATP2C1,WRN,MRE11A,FEN1 |
| ubiquitin binding | OTUB1B,UBAP1,NSFL1C,NPLOC4,NUP62,CXCR4,RNF168,PER2,USP16,OTUB1A |
| protein tyrosine kinase activity | BMX,TNK2B,ERBB4A,MAP2K1,MAP2K5,Fert2,JAK2A,TESK2,CAMKK2,FGFR1A |
| protein binding | UBE2H,PAFAH1B1,NFKB1,PTPRA,THRAP3,EMP1,THAP11,IL24,ZNF167,ZKSCAN4 |
| protein serine/threonine/tyrosine kinase activity | PRKAA2,DYRK3,DYRK1B,CLK1,AURKB,PRKCG,TESK1,DSTYK,AURKC,TTK |
| protein serine/threonine kinase activity | RPS6KA5,TTBK2,PRPF4B,SLK,CDK5,CAMK2D1,ROCK2,TRIO,CDK14,ROCK2B |
Interacting Protein
DYRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK2.
DYRK4;WDR62;SP100;IKZF1;ZBTB9;KXD1;LZTS2
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