DYRK1A
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Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -
Overview
Minibrain (MNBH) is also known as DYRK1 and is the human homolog of the mnb gene in Drosophila and is mapped on human chromosome 21q22.2,Which is within the down syndrome critical region. MNBH may be involved in the signaling pathway that controls cell proliferation and is thought to regulate neuronal differentiation and apoptosis by phosphorylating Hip-1. -
Synonyms
DYRK1A;dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A;DYRK, DYRK1, MNBH;dual specificity tyrosine-phosphorylation-regulated kinase 1A;hMNB;MNB/DYRK protein kinase;serine/threonine kinase MNB;mnb protein kinase homolog hp86;protein kinase minibrain homolog;dual specificity YAK1-related kinase;serine/threonine-specific protein kinase;MNB;DYRK;HP86;MNBH;MRD7;DYRK1
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Chicken
- Insect Cell
- E.coli
- Mammalian Cell
- Wheat Germ
- Sf9 Insect Cell
- HEK293
- Mammalian cells
- Insect (sf21)
- GST
- His
- Non
- Flag
- His&Fc&Avi
Involved Pathway
DYRK1A involved in several pathways and played different roles in them. We selected most pathways DYRK1A participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,G0 and Early G1, which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | ANKLE2,NIPBLA,RAD9,DMC1,SPC24,ARPP19A,MAU2,INCENP,DCTN3,TUBGCP4 |
| G0 and Early G1 | E2F4,LIN54,MYBL2,PIANP,TOP2A,LIN9,LIN52,LIN37 |
| Mitotic G1-G1/S phases | LIN37,TOP2A,MYBL2,LIN9,LIN52,MYCA,LIN54 |
| Hedgehog signaling pathway | FBXW11,SAP18,PRKACA,IHHB,SKI,WNT2B,WNT9B,PTCH2,WNT11,WNT2BA |
| Cell Cycle, Mitotic | AHCTF1,TUBGCP4,TUBG1,LMNB1,TMEM188,CENPE,PANE1,LEMD3,MASTL,CDKN2C |
Protein Function
DYRK1A has several biochemical functions, for example, ATP binding,identical protein binding,non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK1A itself. We selected most functions DYRK1A had, and list some proteins which have the same functions with DYRK1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TNNI1,CLOCKB,DDX18,ALOX15,ATP7A,KATNAL1,C17orf59,CYB561,SEC22B,EFCAB12 |
| protein tyrosine kinase activity | EPHA7,BLK,MAP2K5,PDGFRB,EPHA2A,ERBB4A,CLK2,PTK6B,KITB,AXL |
| protein serine/threonine/tyrosine kinase activity | MAP2K2,RPS6KB1,MAP2K1,RPS6KA1,PRKCG,DYRK2,DYRK1AA,AURKC,AKT1,SGK1 |
| protein self-association | AGXT,TMEM43,NKX3-1,TMEM190,ADAM8,MDH2,VAMP2,AGA,SVIP,SLC9A3R1 |
| tau protein binding | AATF,HDAC6,APOE,FKBP4,BIN1,S100B,SERPINB1A,PPP2R2A,SNCA |
| non-membrane spanning protein tyrosine kinase activity | MATK,JAK2B,FES,RIPK2,FRK,SRMS,LYN,CLK1,PRKCD,ZNF143B |
| identical protein binding | ADIPOQ,RILPL2,SNCA,CDC42,PAFAH1B3,APLP1,GCG,SP100,PRPF19,CALCA |
| ATP binding | TRPM4,SYN1,NSFA,DQX1,ATP1A1A.2,BMPR1AB,ADCY1,CLCN5,BAT1,MYH6 |
| protein kinase activity | MAP3K1,NEK2,MAPK14A,SGK3,PINK1,GUCY2E,NPRL2,FGFR1B,CSNK1DB,STK4 |
Interacting Protein
DYRK1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK1A here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK1A.
DCAF7;YWHAG;RB1;RBL1;TROAP;LZTS2;YWHAE
DYRK1A Related Signal Pathway
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References
- Kida, E; Walus, M; et al. FORM OF DUAL-SPECIFICITY TYROSINE-(Y)-PHOSPHORYLATION-REGULATED KINASE 1A NONPHOSPHORYLATED AT TYROSINE 145 AND 147 IS ENRICHED IN THE NUCLEI OF ASTROGLIAL CELLS, ADULT HIPPOCAMPAL PROGENITORS, AND SOME CHOLINERGIC AXON TERMINALS. NEUROSCIENCE 195:112-127(2011).
- Lilienthal, E; Kolanowski, K; et al. Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes. BMC BIOCHEMISTRY 11:-(2010).
