DUX4
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Official Full Name
double homeobox 4 -
Overview
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). -
Synonyms
DUX4;double homeobox 4;double homeobox protein 4;double homeobox protein 10;double homeobox protein 4/10;double homeobox protein DUX10;DUX10
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUX4-2957H | Recombinant Human DUX4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DUX4-2958H | Recombinant Human DUX4 Protein, GST-tagged | E.coli | Human | GST | 263-424 aa |
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| DUX4-4133HF | Recombinant Full Length Human DUX4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 424 amino acids |
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| DUX4-5857H | Recombinant Human DUX4 protein, His-tagged | E.coli | Human | His | 327-424aa |
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Involved Pathway
DUX4 involved in several pathways and played different roles in them. We selected most pathways DUX4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
DUX4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DUX4 itself. We selected most functions DUX4 had, and list some proteins which have the same functions with DUX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
DUX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUX4.
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References
- Sacconi, S; Salviati, L; et al. Facioscapulohumeral muscular dystrophy. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:607-614(2015).
- Ferri, G; Huichalaf, CH; et al. Direct interplay between two candidate genes in FSHD muscular dystrophy. HUMAN MOLECULAR GENETICS 24:1256-1266(2015).
