DUSP1

  • Official Full Name

    dual specificity phosphatase 1

  • Overview

    The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

  • Synonyms

    DUSP1;dual specificity phosphatase 1;PTPN10;dual specificity protein phosphatase 1;CL100;HVH1;MKP 1;MAP kinase phosphatase 1;protein-tyrosine phosphatase CL100;dual specificity protein phosphatase hVH1;serine/threonine specific protein phosphata

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Chicken
  • Mouse
  • Wheat Germ
  • Mammalian Cell
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Non
  • His
  • GST
  • His&GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DUSP1-28071TH Recombinant Human DUSP1 Wheat Germ Human Non 367 amino acids
DUSP1-12297Z Recombinant Zebrafish DUSP1 Mammalian Cell Zebrafish His
DUSP1-1347R Recombinant Rhesus monkey DUSP1 Protein, His-tagged Mammalian Cell Rhesus macaque His
DUSP1-32H Recombinant Human DUSP1 protein, GST-tagged Wheat Germ Human GST 305-367 a.a.
DUSP1-3684C Recombinant Chicken DUSP1 Mammalian Cell Chicken His
DUSP1-4874M Recombinant Mouse DUSP1 Protein Mammalian Cell Mouse His
DUSP1-852H Recombinant Human DUSP1, His-tagged E.coli Human His 1-340 a.a.
DUSP1-01H Recombinant Human DUSP1 protein, His-GST-tagged E.coli Human His&GST Val175~Cys367
DUSP1-1172R Recombinant Rhesus Macaque DUSP1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
DUSP1-1172R-B Recombinant Rhesus Macaque DUSP1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DUSP1-130HF Recombinant Full Length Human DUSP1 Protein In Vitro Cell Free System Human Full L. 367 amino acids
DUSP1-1392H Recombinant Human DUSP1 Protein, His-tagged E.coli Human His Val175-Cys367
DUSP1-2561M Recombinant Mouse DUSP1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DUSP1-2561M-B Recombinant Mouse DUSP1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    DUSP1 involved in several pathways and played different roles in them. We selected most pathways DUSP1 participated on our site, such as ARMS-mediated activation,ATF-2 transcription factor network,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DAP12 interactions DUSP5,CSF2RA,THEM4,SPTA1,PTPRA,DAB2IPB,NRG3,PAQR3A,CNKSR1,DUSP7
    Axon guidance KALRN,NETO2,SPTA1,SCN2B,MAPK1,NRP1A,DUSP4,EVL,SEMA3A,CLTC
    Developmental Biology EFNA1B,GFRA2,NTN1A,SREBF2,LGI1B,MYL12B,PLXNC1,LGI2,MED9,MYL9
    ARMS-mediated activation SPTA1,SPNA2,FRS2A,DUSP6,PSMA8,HBEGF,PSMD9,FGF18B,SPRED1,PHB
    ATF-2 transcription factor network CBFB,JUN,JUNB,CDK4,JUND,MAPK14,KCNA3,POU2F1,JDP2,CSRP2
    Direct p53 effectors PCBP4,DDB2,PLK3,CSE1L,DUSP5,RNF144B,GDF15,EDN2,TRIAP1,BNIP3L
    DAP12 signaling PHB,GRAP2B,PAQR3B,NRG3,SPTB,AGO2,SPRED1,PAQR3A,THEM4,DUSP4
    Cytokine Signaling in Immune system IL1RN,DUSP10,IFIT14,KPNA3,IFIT8,TRIM3,NUPL2,TRIM26,EIF4G2,SOCS3A

    Protein Function

    DUSP1 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,non-membrane spanning protein tyrosine phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP1 itself. We selected most functions DUSP1 had, and list some proteins which have the same functions with DUSP1. You can find most of the proteins on our site.

    Function Related Protein
    non-membrane spanning protein tyrosine phosphatase activity PTPN4,PTPN9,PTPN11,PTPN18,PTPN12,ACP1
    protein binding IQSEC3,NABP1,DDX18,RAB32,UBL4B,CX3CR1,RFX4,GTPBP10,C1QL1,ARL4C
    protein tyrosine/threonine phosphatase activity TENC1,DUSP2,DUSP19,DUSP4,SACM1LB,PXYLP1,PTPRQ,CTDSPL2A,SACM1LA,CTDSPL2B
    MAP kinase tyrosine/serine/threonine phosphatase activity DUSP4,PXYLP1,SACM1LB,TENC1,CTDSPL2A,DUSP10,DUSP14,SGPP2,DUSP18,CTDSPL2B
    protein tyrosine/serine/threonine phosphatase activity PTP4A3,PTPMT1,CDC14B,DUPD1,CDKN3,CDC14C,SACM1LB,DUSP26,DUSP22,DUSP12

    Interacting Protein

    DUSP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP1.

    MAPK3;MAPK14;MAPK1;SKP2;UBB

    Resources

    Research Area

    Phosphatases and Regulators
    Phosphatases in the Akt Pathway
    Head and Neck Cancer Biomarkers

    References

    • Harati, K; Slodnik, P; et al. Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1629-1636(2015).
    • Ying, HJ; Kang, YH; et al. MiR-127 Modulates Macrophage Polarization and Promotes Lung Inflammation and Injury by Activating the JNK Pathway. JOURNAL OF IMMUNOLOGY 194:1239-1251(2015).

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