DUOX2
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Official Full Name
dual oxidase 2 -
Overview
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. -
Synonyms
DUOX2;dual oxidase 2;dual oxidase like domains 2;flavoprotein NADPH oxidase;LNOX2;NADH/NADPH thyroid oxidase p138 tox;NADPH oxidase/peroxidase DUOX2;NADPH thyroid oxidase 2;nicotinamide adenine dinucleotide phosphate oxidase;P138(TOX);P138 TOX;THOX2;Dual oxidase2;Large NOX 2;Long NOX 2;NOXEF2;p138 thyroid oxidase;Thyroid oxidase 2;dual oxidase-like domains 2;NADH/NADPH thyroid oxidase p138-tox;TDH6;P138-TOX
Recombinant Proteins
- Rat
- Human
- Mammalian Cells
- Rabbit
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUOX2-1969R | Recombinant Rat DUOX2 Protein | Mammalian Cells | Rat | His |
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| DUOX2-810H | Recombinant Human DUOX2 | Mammalian Cells | Human | His |
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| CPBT-32950RH | Rabbit Anti-Human DUOX2 Polyclonal Antibody | Rabbit | Human | Non |
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| DUOX2-1628R | Recombinant Rat DUOX2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DUOX2-1628R-B | Recombinant Rat DUOX2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Duox2-196R | Recombinant Rat Duox2 Protein, His-tagged | E.coli | Rat | His | Asp1229~Phe1517 |
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| DUOX2-2825H | Recombinant Human DUOX2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| DUOX2-2825H-B | Recombinant Human DUOX2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
DUOX2 involved in several pathways and played different roles in them. We selected most pathways DUOX2 participated on our site, such as Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUOX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone synthesis | SLC26A4,IYD,GPX3,GPX6,GNAS,TG,ITPR3,TTF2,TSHB,ATP1B3 |
Protein Function
DUOX2 has several biochemical functions, for example, NAD(P)H oxidase activity,calcium ion binding,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUOX2 itself. We selected most functions DUOX2 had, and list some proteins which have the same functions with DUOX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP2AD2,CYP21A2,CYP2N13,CYP2P9,CYP46A1,CYP2P8,CYP2C70,CYP17A2,BACH1,PTGS2 |
| calcium ion binding | CGREF1,CABP1A,CAPN12,PITPNM2,CRB1,PITPNM3,EGFL6,MEGF6,CACNA1SA,NOTCH4 |
| peroxidase activity | GPX8,GPX4B,GPX7,PTGS1,CYGB,PXDN,GPX6,EPX,MPX,MPO |
| NAD(P)H oxidase activity | DERL3,CYB5R4,KMO,AIFM1,NOX4 |
Interacting Protein
DUOX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUOX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUOX2.
Resources
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References
- Sommer, F; Backhed, F; et al. The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium. MUCOSAL IMMUNOLOGY 8:372-379(2015).
- Li, ZY; Jiang, WY; et al. An essential role of NAD(P)H oxidase 2 in UVA-induced calcium oscillations in mast cells. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 14:414-428(2015).
