DRD5
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Official Full Name
dopamine receptor D5 -
Overview
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This receptor is neuron specific, localized primarily within limbic regions of the brain. Defects in DRD5 are a cause of blepharospasm and may be a cause of schizophrenia. -
Synonyms
DRD5;dopamine receptor D5;DBDR;DRD1B;DRD1L2;MGC10601;D(1B) dopamine receptor;OTTHUMP00000158603;dopamine D5 receptor;dopamine receptor D1B;d(5) dopamine receptor;D1beta dopamine receptor
Recombinant Proteins
- Human
- Rat
- Mus musculus
- Xenopus laevis
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
DRD5 involved in several pathways and played different roles in them. We selected most pathways DRD5 participated on our site, such as Amine ligand-binding receptors,Calcium signaling pathway,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR ligand binding | TAS2R16,OPN1MW,PENKA,LPAR2A,GRP,INSL5,OPN1LW2,APLN,CYSLTR1,QRFPR |
| Class A/1 (Rhodopsin-like receptors) | ADRB2,CCR8,OXGR1,OXER1,GPR31B,UTS2D,NPSR1,S1PR5B,CCR6,CNR2 |
| GPCR downstream signaling | CCK,CALCA,OXTRL,OPN1SW,RHOC,ANXA1,ADRA2B,PTHRP2,INSL3,UTS2D |
| Amine ligand-binding receptors | CHRM2,DRD2,CHRM3,ADRa1A,ADRA1B,CHRM1,TAAR1,HRH3,ADRA2C,ADRA2A |
| Dopaminergic synapse | CREB3L1,SCN1A,PPP2R3C,ITPR1,FOS,CREB3L3,CALM2,GNG8,PPP2R2B,GNG11 |
| Dopamine receptors | DRD4,DRD2,DRD1,DRD3 |
| G alpha (s) signalling events | SCT,CRH,INSL3,RAMP3,PTH2,RXFP2,PDE10A,GPBAR1,VIP2,ADCYAP1B |
| Calcium signaling pathway | CACNA1C,CALM1B,GRPR,CALM1A,PRKACBB,TACR3A,CACNA1DA,CALM3A,TMEM8C,PTGER1B |
Protein Function
DRD5 has several biochemical functions, for example, G-protein coupled amine receptor activity,dopamine binding,dopamine neurotransmitter receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD5 itself. We selected most functions DRD5 had, and list some proteins which have the same functions with DRD5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled amine receptor activity | DRD4,DRD1B,TAAR8A,DRD1,DRD3,TAAR7D,TAAR7A,DRD4-RS,DRD1A,TAAR2 |
| dopamine binding | SLC6A3,GPR143,TH,ADRB2,DRD1A,DRD3,DRD2L,DRD2,DRD1,DRD2B |
| dopamine neurotransmitter receptor activity | DRD4,DRD2B,DRD4A,DRD2A,DRD1B,DRD4B,DRD4-RS,DRD1A,DRD1,DRD7 |
| dopamine neurotransmitter receptor activity, coupled via Gs | DRD1,DRD1B,DRD1A |
Interacting Protein
DRD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD5.
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References
- Hawi, Z; RCummins, TD; et al. The molecular genetic architecture of attention deficit hyperactivity disorder. MOLECULAR PSYCHIATRY 20:289-297(2015).
- Sriram, K; Jefferson, AM; et al. Neurotoxicity following acute inhalation of aerosols generated during resistance spot weld-bonding of carbon steel. INHALATION TOXICOLOGY 26:720-732(2014).
