DRD3
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Official Full Name
dopamine receptor D3 -
Overview
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is expressed in phylogenetically older regions of the brain, suggesting that it plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). -
Synonyms
D3DR;ETM1;FET1;MGC149204;MGC149205;dopamine receptor D3;DRD3;D(3) dopamine receptor;OTTHUMP00000214909;OTTHUMP00000214910;OTTHUMP00000214911;essential tremor 1;dopamine D3 receptor
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Zebrafish
- Mus musculus
- Pan troglodytes
- Chlorocebus Aethiops
- E.coli
- Mammalian Cells
- HEK293
- His
- Flag
- Avi
- Fc
- GST
Involved Pathway
DRD3 involved in several pathways and played different roles in them. We selected most pathways DRD3 participated on our site, such as Amine ligand-binding receptors,Class A/1 (Rhodopsin-like receptors),Dopamine receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | NMU,NMBB,GPBAR1,ADRa1A,CHRM1,ADORA2B,OXTRL,LTB4R,CHRM2,OPN1SW1 |
| G alpha (i) signalling events | APLN,RGR,RGS10,ADORA3,ANXA1C,PNOC,LPAR2A,LPAR5A,DRD4,S1PR1 |
| Amine ligand-binding receptors | ADRA2A,ADRA2C,ADRB3,ADRA2B,ADRB1,DRD5,CHRM4,CHRM3,TAAR1,CHRM1 |
| GPCR ligand binding | CASR,EMR1,NPB,UTS2,OPN1LW2,FZD10,EDN1,OXER1,GPR31,GNB5A |
| Dopamine receptors | DRD1,DRD2,DRD4,DRD5 |
| GPCR downstream signaling | NTS,OR52J3,CCL27,GHRH,SSTR5,EDN2,ARHGEF1A,RAMP2,LTB4R,TRPC7 |
| Dopaminergic synapse | SCN1A,GRIN2B,PRKCG,PRKACB,PRKCA,GNG5,PLCB4,CALY,GNG10,CALM1 |
| GPCRs, Class A Rhodopsin-like | OPN3,GPR1,SSTR5,OPN1LW,ACKR4,SSTR4,NPFFR2,GPR18,CCR3,GPR3 |
Protein Function
DRD3 has several biochemical functions, for example, D1 dopamine receptor binding,G-protein coupled amine receptor activity,dopamine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD3 itself. We selected most functions DRD3 had, and list some proteins which have the same functions with DRD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EIF3E,CDC23,EIF4EBP1,ACOT7,DAPP1,PSMD3,DRG2,UTP11L,GPR177,PRADC1 |
| drug binding | CHRNB3,DRD1A,HMGCS1,UGT1A7,CYP2C9,GLRB,CHRM1,PDE10A,PDE4D,FABP1 |
| protein domain specific binding | VAPA,HIST1H4L,MPP7,ODF1,CACNB2,HAND2,KCNN2,ERCC1,IL1B,SERPINB1A |
| dopamine neurotransmitter receptor activity, coupled via Gi/Go | DRD2,DRD2B,DRD2L,DRD4A,DRD2A,DRD4B,DRD4-RS,DRD4 |
| D1 dopamine receptor binding | GNAS,AGTR1A,ARRB2,PTPN11,CAV2,ATP1A3,DLG4 |
| dopamine binding | DRD5,ADRB2,DRD4,DRD2B,TH,DRD1,DRD2L,GPR143,SLC6A3,DRD1A |
| G-protein coupled amine receptor activity | DRD1A,DRD1,GPR21,TAAR8B,DRD4A,TAAR8C,TAAR2,TAAR13C,TAAR9,TAAR7F |
Interacting Protein
DRD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD3.
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