DOCK2
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Official Full Name
dedicator of cytokinesis 2 -
Overview
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011] -
Synonyms
DOCK2;dedicator of cytokinesis 2;dedicator of cytokinesis protein 2;dedicator of cyto-kinesis 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DOCK2-402H | Recombinant Human DOCK2 Protein, His-tagged | E.coli | Human | His | Ile390~Glu635 | |
| DOCK2-2805H | Recombinant Human DOCK2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DOCK2-503HCL | Recombinant Human DOCK2 cell lysate | Human | Non |
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| DOCK2-1981H | Recombinant Human DOCK2 Protein (Ile390-Glu635), His tagged | E.coli | Human | His | Ile390-Glu635 |
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| DOCK2-3935HF | Recombinant Full Length Human DOCK2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 336 amino acids |
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Involved Pathway
DOCK2 involved in several pathways and played different roles in them. We selected most pathways DOCK2 participated on our site, such as Chemokine signaling pathway,Disease,Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIV Infection | APOBEC3G,CHMP4C,PACS1,TAF1L,NMT2,PSTPIP2,AP1M2,AP1B1,NPM1,RCC1 |
| Infectious disease | IPO5,LTF,VPS37A,AP1G1,STX1B,KPNA5,CCDC167,PACS1,RCC1,PDCD6IP |
| Fc gamma R-mediated phagocytosis | PLCG1,FCGR1,PPAP2A,VAV1,RAC2,PIK3CG,MAP2K1,PIP5K1C,PLCG2,VAV2 |
| Hemostasis | KIF15,S100A10B,ESAMA,BSG,PRKCHB,HRG,GNA13B,ITGB3A,IRF2,DOCK11 |
| Chemokine signaling pathway | Cxcl15,CXCL9,CCL17,CCL4L1,GNG11,AKT1,GNGT1,GNG12,PIK3CD,GM1987 |
| Disease | SFTPC,TLR6,NPM1,APOBEC3G,CFTR,AP2B1,CCR5,COBRA1,SFTPB,EPM2A |
| Factors involved in megakaryocyte development and platelet production | KIF11,RACGAP1,CABLES1,KIF5B,HBBE3,KIF5A,KIF2B,MFN2,CENPE,HMG20B |
| Host Interactions of HIV factors | AP1M2,AP1S1,AP1B1,PSIP1,PACS1,RCC1,APOBEC3G,AP1G1,PPIAL4A |
Protein Function
DOCK2 has several biochemical functions, for example, GTPase activator activity,Rac guanyl-nucleotide exchange factor activity,T cell receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK2 itself. We selected most functions DOCK2 had, and list some proteins which have the same functions with DOCK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rac guanyl-nucleotide exchange factor activity | PREX2,SPATA13,FARP1,VAV3,ARHGEF2,ARHGEF4,VAV1,FARP2,ALS2 |
| protein binding | DLC1,PVRL2,SIKE1,DDX42,GTPBP10,NUP35,POLD1,RAB27A,TYRP1,KLF15 |
| GTPase activator activity | TBC1D16,ARFGAP1,NIPAL1,RAP1GAP2,ARHGEF1,TBC1D10A,RGS17,NCKAP1L,ARHGAP32,TBC1D9 |
| T cell receptor binding | H2-Q10,CD3G,FYN,CD1d1,HLA-A,EPS8L1,CD3E |
Interacting Protein
DOCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK2.
RAC1;PLSCR1;CCNDBP1;KRTAP5-9;TRIM23
DOCK2 Related Signal Pathway
Resources
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References
- Eguchi, K; Yoshioka, Y; et al. The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells. EXPERIMENTAL CELL RESEARCH 319:2179-2195(2013).
- Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).
