DNM1L
-
Official Full Name
dynamin 1-like -
Overview
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related;subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do;not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a;role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts;encoding different isoforms. These transcripts are alternatively polyadenylated. -
Synonyms
DNM1L;dynamin 1-like;dynamin-1-like protein;DRP1;DVLP;DYMPLE;HDYNIV;VPS1;dynamin-like protein 4;dynamin-like protein IV;Dnm1p/Vps1p-like protein;dynamin-related protein 1;dynamin family member proline-rich carboxyl-terminal domain less;DLP1
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- His&Myc
Involved Pathway
DNM1L involved in several pathways and played different roles in them. We selected most pathways DNM1L participated on our site, such as Apoptosis,Apoptotic execution phase,Programmed Cell Death, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNM1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptotic execution phase | SPNA2,STK24A,PLECA,HIST1H1B,STK24B,CTNNB2,H1F0,HIST1H1A,CASP8L1,DSG1 |
| Programmed Cell Death | CASP6L2,MLKL,PKP1,GAS2,PLECA,BMX,SATB1,PANK1A,BAXB,HMGB2A |
| Apoptosis | BAXA,PTBP3,CASP6L2,LMNB1,CASP12,IL1B,CLSPN,BIRC7,ADD1,CTNNB1 |
| Synaptic Vesicle Pathway | SYN3,SYN1,PARK7,CPLX2,SYP,SYN2,STX1B |
| TNF signaling pathway | PGAM5,Ccl12,RIPK1,SOCS3,CREB3L2,MAPK12,MLKL,IL15,RELA,ITCH |
Protein Function
DNM1L has several biochemical functions, for example, GTP binding,GTPase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNM1L itself. We selected most functions DNM1L had, and list some proteins which have the same functions with DNM1L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activity | RAB17,TUBE1,GNA14,TUBA8L,RAB32,ARL8A,RAB43,GTPBP2,RAB3AB,GNGT2 |
| ubiquitin protein ligase binding | FHIT,CD40,GABARAPL2,ACTG1,ARRB2,Fzd4,NGFR,TOLLIP,GABARAP,SCAMP3 |
| protein binding | ZNF238,MAPRE2,CHD7,RSPO1,MTX2,CCDC86,KLHL2,STMN2,DUSP26,CSNK1D |
| GTP binding | RHOBTB1,DNM1B,GCH1,ARL17B,RAB5AA,ATL1,DIRAS1B,RAC2,RAB11BB,TUBA4A |
| protein homodimerization activity | PAFAH1B1,ZBTB4,HOGA1,SPATA24,TSG101,TRIM8,PDXK,LRRFIP1,TFRC,ANXA9 |
| identical protein binding | LDHB,TOPBP1,GUCY2E,KCNH2,LZTFL1,AGXT2L2,SMAD4,CLDN11,SCUBE1,C1QTNF2 |
| lipid binding | SNX10B,APOA2,APOEB,APOC2,OSBPL11,Ar,PITPNM3,CYTH4,PACSIN3,FAM123B |
Interacting Protein
DNM1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNM1L here. Most of them are supplied by our site. Hope this information will be useful for your research of DNM1L.
LRRK2;MIEF2;MIEF1
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