DNAJC19
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Official Full Name
DnaJ (Hsp40) homolog, subfamily C, member 19 -
Overview
The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Several transcript variants, some protein-coding and some not, have been found for this gene. -
Synonyms
DNAJC19;DnaJ (Hsp40) homolog, subfamily C, member 19;mitochondrial import inner membrane translocase subunit TIM14;Pam18;Tim14;TIMM14;DnaJ homolog subfamily C member 19;homolog of yeast TIM14;TIM 14;TIMM 14;translocase of the inner mitochondrial membrane 14
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DNAJC19-12079H | Recombinant Human DNAJC19, GST-tagged | E.coli | Human | GST | 1-116a.a. | |
| DNAJC19-11024Z | Recombinant Zebrafish DNAJC19 | Mammalian Cell | Zebrafish | His |
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| DNAJC19-1290R | Recombinant Rhesus monkey DNAJC19 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| DNAJC19-26773TH | Recombinant Human DNAJC19, His-tagged | E.coli | Human | His | 98 amino acids |
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| DNAJC19-2756H | Recombinant Human DNAJC19 Protein, His-tagged | E.coli | Human | His | 19-116 a.a. |
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| DNAJC19-3405H | Recombinant Human DNAJC19, His-tagged | E.coli | Human | His |
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| DNAJC19-6875HCL | Recombinant Human DNAJC19 293 Cell Lysate | HEK293 | Human | Non |
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| DNAJC19-1115R | Recombinant Rhesus Macaque DNAJC19 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| DNAJC19-1115R-B | Recombinant Rhesus Macaque DNAJC19 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Dnajc19-2606M | Recombinant Mouse Dnajc19 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
DNAJC19 involved in several pathways and played different roles in them. We selected most pathways DNAJC19 participated on our site, such as Metabolism of proteins,Mitochondrial protein import, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNAJC19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial protein import | MTX1,TOMM70A,CHCHD4,TIMM17A,TIMM44,TIMM10,TIMM9,PAM16,GRPEL1,TIMM50 |
| Metabolism of proteins | SLC25A12,TMED2,ADAMTSL1,DMBT1,LMAN2L,MUC4,EXOC3,EEF1B2,SEC63,MGAT4B |
Protein Function
DNAJC19 has several biochemical functions, for example, ATPase activator activity,protein binding,contributes_to protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNAJC19 itself. We selected most functions DNAJC19 had, and list some proteins which have the same functions with DNAJC19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KLHL2,PNRC2,ZNF593,CASP10,INPP5D,DDX58,C6orf211,PMM2,USF1,SMC2 |
| contributes_to protein transporter activity | DNAJC15,TOMM5,VPS29 |
| ATPase activator activity | MYBPC3,DNAJB1,TOR1AIP2,DNAJC10,AHSA1L,DNAJB6,ATP1B3,ATP1B2,TOR1AIP1,DNAJC15 |
Interacting Protein
DNAJC19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNAJC19 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNAJC19.
TFAP2A;Cct2;FBXO31
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References
- Taboada, X; Hermida, M; et al. Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus). G3-GENES GENOMES GENETICS 4:1871-1880(2014).
- Richter-Dennerlein, R; Korwitz, A; et al. DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling. CELL METABOLISM 20:158-171(2014).
