DLX2
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Official Full Name
distal-less homeobox 2 -
Overview
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. -
Synonyms
DLX2;distal-less homeobox 2;homeobox protein DLX-2;DII A;homeobox protein TES-1;Dlx-2;Tes-1;AW121999
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DLX2-2691H | Recombinant Human DLX2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DLX2-282H | Recombinant Human DLX2 Protein, His-tagged | E.coli | Human | His |
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| DLX2-4635M | Recombinant Mouse DLX2 Protein | Mammalian Cell | Mouse | His |
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| DLX2-6907HCL | Recombinant Human DLX2 293 Cell Lysate | HEK293 | Human | Non |
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| DLX2-2404M | Recombinant Mouse DLX2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DLX2-2404M-B | Recombinant Mouse DLX2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DLX2-4002HF | Recombinant Full Length Human DLX2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 328 amino acids |
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Involved Pathway
DLX2 involved in several pathways and played different roles in them. We selected most pathways DLX2 participated on our site, such as SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SIDS Susceptibility Pathways | MAP2,TPH2,CDCA7L,MAZ,DEAF1,YBX1,MBD1,PLP1,ASCL1,POU3F2 |
Protein Function
DLX2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLX2 itself. We selected most functions DLX2 had, and list some proteins which have the same functions with DLX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | PHOX2A,SP3,NHLH2,PHF21A,ZNF792,DBP,SUV39H1,PHF21B,BARHL2,ETV7 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | NKX2,FEZF2,TRP53,MAFBA,ZGLP1,CSRNP3,REST,MYF5,CSRNP2,TP53 |
| transcription factor activity, sequence-specific DNA binding | NFAT5,NKX2-6,NR6A1A,FOXO6,ZFP42,ZNF239,ZBTB25,ZFP382,TCF3B,CSRNP2 |
| chromatin binding | PBX2,MORF4L1,PRKAA2,HMG20B,LRWD1,SP3,ERCC6,PELP1,SREBF1,HMGB2 |
| protein binding | SNRPD2,SEC61G,ZNF511,Reln,CD244,VPS33B,PINX1,SIGLEC6,HIST1H4B,PPFIA4 |
| single-stranded RNA binding | NXF1,CBX4,LSM14A,AGO2,CBX8,JMJD6,IFIH1,POLR2G,ENDOV,IFIT5 |
Interacting Protein
DLX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLX2.
GRN;gag;PIK3R1
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References
- Pfenninger, CV; Steinhoff, C; et al. Prospectively Isolated CD133/CD24-Positive Ependymal Cells from the Adult Spinal Cord and Lateral Ventricle Wall Differ in Their Long-Term In Vitro Self-Renewal and In Vivo Gene Expression. GLIA 59:68-81(2011).
- Chen, XP; Li, L; et al. Rapid adaptation of molecular resources from zebrafish and medaka to develop an estuarine/marine model. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 149:647-655(2009).
