DICER1
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Official Full Name
dicer 1, ribonuclease type III -
Overview
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] -
Synonyms
DICER1;dicer 1, ribonuclease type III;DCR1;MNG1;Dicer;HERNA;RMSE2;endoribonuclease Dicer;K12H4.8-LIKE;helicase MOI;helicase-moi;Dicer1, Dcr-1 homolog;multinodular goitre 1;helicase with RNAse motif;dicer 1, double-stranded RNA-specific endoribonuclease;DCR-1;Dicer-1;CG4792 gene product from transcript CG4792-RA;Dicer 1 ribonuclease type III;Dicer-1 protein;DICER_HUMAN;Endoribonuclease Dcr-1;ORFNames: CG4792;CG4792-PA;Dcr-1-PA;cg4792;Dcr;dcr 1;Dmel\CG4792;Antagonist decoy receptor for TRAIL/Apo 2L;CD263;Cytotoxic TRAIL receptor 3;DCR1 TNFR;Dctrailr1;Decoy Receptor 1;Decoy TRAIL receptor 1;Decoy TRAIL receptor without death domain;LIT;Lymphocyte inhibitor of TRAIL;MGC149501;MGC149502;mSOB;TNF receptor family member SOB;TNF receptor homolog 1;TNF Related Apoptosis Inducing Ligand Receptor 3;TNF-re ated apoptosis inducing ligand receptor 3;Tnfrh1;TNFRSF10C;Tnfrsf1al1;Tnfrsf23;TRAIL R3;TRAIL receptor 3;TRAIL Receptor Without An Intracellular Domain;TRAILR3;TRID;Tumor necrosis factor receptor p60 homolog 1;Tumor Necrosis Factor Receptor Superfamily Member 10C;Tumor necrosis factor receptor superfamily member 23;Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Recombinant Proteins
- Rhesus macaque
- Human
- Chicken
- Zebrafish
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- Human cells
- E. coli
- HEK293T
- Mammalian cells
- Mamanlian cells
- His
- Myc&DDK
- GST
- Flag
- His&Fc&Avi
Involved Pathway
DICER1 involved in several pathways and played different roles in them. We selected most pathways DICER1 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DICER1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | TP53,SOX4,DNMT3B,PDGFRA,TPM1,ST14,BAK1,EP300,ERBB2,EZR |
Protein Function
DICER1 has several biochemical functions, for example, ATP binding,DNA binding,deoxyribonuclease I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DICER1 itself. We selected most functions DICER1 had, and list some proteins which have the same functions with DICER1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endoribonuclease activity | TSNAX,RNASET2,SMG6,TSN,NOB1,RCL1,RNASEKA,PLD6,RNASEK,AGO2 |
| contributes_to pre-miRNA binding | XPO5,RAN,TARBP2 |
| DNA binding | ZNF285A,HIST1H2BL,TMEM18,ZNF12,NR0B1,TBX16,PUF60,NKX3-1,GLI1,ZFPM1 |
| protein domain specific binding | SLC34A2,BASP1,MLF1,RCC2,TACC2,CEP68,POU2F2,AIDA,RAP2B,NFE2L2 |
| helicase activity | SMARCAD1,DDX6,DDX39,DDX19B,DHX34,HLTF,GTF2F2B,TDRD12,DNA2,GTF2F2 |
| ATP binding | ACTC1A,DDX52,PAPOLA,NME2B.1,KIF5C,GRK7B,SRX1,PANK1B,EPHB2B,DHX9 |
| protein binding | RANBP3,PHC2,TFAP2A,ALPP,GATC,ARGLU1,IQSEC3,SET,TRAPPC5,C7orf25 |
| metal ion binding | CA,CXXC1B,PDE9A,CYP2X8,GDPD4,PPEF2,PVALB5,ZFYVE27,ZNF498,ADK |
| double-stranded RNA binding | OASL1,DHX58,EIF2C3,DHX30,YRDC,MSN,SLC3A2,OAS1,TUBB4B,EIF4A1 |
Interacting Protein
DICER1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DICER1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DICER1.
AGO2;TARBP2
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References
- Devouassoux-Shisheboran, M; et al. Ovarian cancer: molecular biology. ONCOLOGIE 16:306-312(2014).
- Stewart, CJR; Alexiadis, M; et al. An immunohistochemical and molecular analysis of problematic and unclassified ovarian sex cord stromal tumors. HUMAN PATHOLOGY 44:2774-2781(2013).
