DHX30
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Official Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 30 -
Overview
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein has 97% sequence identity with the mouse HELG protein. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
DHX30;DEAH (Asp-Glu-Ala-His) box polypeptide 30;DDX30, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 30;putative ATP-dependent RNA helicase DHX30;FLJ11214;KIAA0890;DDX30;DEAH box protein 30;DHX30_HUMAN;Ret CoR;retina co-repressor;ATP-dependent RNA helicase DHX30;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 30;RETCOR
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DHX30 involved in several pathways and played different roles in them. We selected most pathways DHX30 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX30 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DHX30 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX30 itself. We selected most functions DHX30 had, and list some proteins which have the same functions with DHX30. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CHD4,SMARCAD1,CHD8,UBE2D2A,MAP3K4,PDS5B,TESK1,GSG2,PIF1,BMPR2A |
| poly(A) RNA binding | DHX32,SNRNP200,RBM10,HNRNPA2B1,ISY1,SURF6,FNDC3B,RPL14,PDIA4,RPS4Y2 |
| chromatin binding | SOX10,CCDC111,CAMTA2,JDP2,LDB2A,MLL1,MEOX1,TADA2A,SMAD6,NSD1 |
| ATP-dependent RNA helicase activity | DDX4,DHX8,DDX41,PL10,TDRD12,DDX3X,BAT1,DDX50,DDX6,DDX10 |
| double-stranded RNA binding | HSPD1,OAS3,TLR8,LRRFIP1,DROSHA,ZNF346,LSM14A,EIF2AK2,STRBP,DGCR8 |
| protein binding | TIMM10,TRAF3IP2,EXOSC3,FRS2,S1PR2,MEN1,C11orf46,AKTIP,OPA1,ATM |
Interacting Protein
DHX30 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX30 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX30.
NR2E3;EIF2AK2;RBL1;CDK9;TBL3
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References
- Antonicka, H; Shoubridge, EA; et al. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. CELL REPORTS 10:920-932(2015).
- Zheng, HJ; Tsukahara, M; et al. The Novel Helicase helG (DHX30) Is Expressed During Gastrulation in Mice and Has a Structure Similar to a Human DExH Box Helicase. STEM CELLS AND DEVELOPMENT 24:372-383(2015).
