DHCR7

  • Official Full Name

    7-dehydrocholesterol reductase

  • Overview

    This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

  • Synonyms

    DHCR7;7-dehydrocholesterol reductase;SLOS, Smith Lemli Opitz syndrome;7 dehydrocholesterol reductase;7 DHC reductase;Delta 7 dehydrocholesterol reductase;Putative sterol reductase SR 2;Sterol Delta;7-DHC reductase;sterol delta-7-reductase;putative sterol reductase SR-2;delta-7-dehydrocholesterol reductase;SLOS

Recombinant Proteins

  • Zebrafish
  • Rat
  • Human
  • Chicken
  • Mouse
  • Bovine
  • Xenopus laevis
  • zebrafish
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • Protein Conjugation
  • In vitro E. coli expression system
  • E.coli
  • E.coli expression system
  • His
  • GST
  • Non
  • His&Fc&Avi
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
DHCR7-11477Z Recombinant Zebrafish DHCR7 Mammalian Cell Zebrafish His
DHCR7-1858R Recombinant Rat DHCR7 Protein Mammalian Cell Rat His
DHCR7-2582H Recombinant Human DHCR7 Protein, GST-tagged Wheat Germ Human GST
DHCR7-4340C Recombinant Chicken DHCR7 Mammalian Cell Chicken His
DHCR7-4553M Recombinant Mouse DHCR7 Protein Mammalian Cell Mouse His
DHCR7-6949HCL Recombinant Human DHCR7 293 Cell Lysate HEK293 Human Non
DHCR7-1516R Recombinant Rat DHCR7 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
DHCR7-1516R-B Recombinant Rat DHCR7 Protein Pre-coupled Magnetic Beads HEK293 Rat
DHCR7-2352M Recombinant Mouse DHCR7 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DHCR7-2352M-B Recombinant Mouse DHCR7 Protein Pre-coupled Magnetic Beads HEK293 Mouse
DHCR7-2510HF Recombinant Full Length Human DHCR7 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 475 amino acids
DHCR7-2800H Recombinant Human DHCR7 Protein, His-tagged, OVA Conjugated Protein Conjugation Human His His449-Ala464
DHCR7-293B Recombinant Bovine DHCR7 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system Bovine His Full L. 1-475aa
DHCR7-479H Recombinant Human DHCR7 Protein, His/GST-tagged E.coli Human His&GST Cys61~Leu153
RFL11704XF Recombinant Full Length Xenopus Laevis 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system Xenopus laevis His Full L. Full Length (1-473)
RFL2095HF Recombinant Full Length Human 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-475)
RFL32768DF Recombinant Full Length Danio Rerio 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system zebrafish His Full L. Full Length (1-478)
RFL34220BF Recombinant Full Length Bovine 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system Bovine His Full L. Full Length (1-475aa)
RFL3431XF Recombinant Full Length Xenopus Tropicalis 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) His Full L. Full Length (1-473)

    Involved Pathway

    DHCR7 involved in several pathways and played different roles in them. We selected most pathways DHCR7 participated on our site, such as Activation of gene expression by SREBF (SREBP),Cholesterol biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHCR7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of cholesterol biosynthesis by SREBP (SREBF) MTF1,INSIG2,SREBF2,NFYAL,YY2,PMVK,INSIG1,NFYBA,NFYBB
    Metabolic pathways AMY2A5,ALOX15B,ALP3,PRPS1L1,ITPK1,ASL,NDUFS8A,KLF15,COX6B1,MTHFR
    Activation of gene expression by SREBF (SREBP) NCOA2,NFYBB,MTF1,NFYBA,SREBF2,CARM1,CYP51A1,NFYAL,HELZ2,PMVK
    Metabolism MOCOS,ADH8B,APOA5,SLC25A14,PLBD1,TMEM195,DTYMK,TPH2,B3GNT3,ARSJ
    cholesterol biosynthesis I DHCR24,EBP,LBR
    Cholesterol biosynthesis LBR,ARV1,PMVK,EBP,CYP51A1,DHCR24,SREBF2
    Metabolism of lipids and lipoproteins MED18,MED7,CPT2,APOA4A,MED31,NFYBA,FABP12,FABP9,SPTLC1,CLPS
    Steroid biosynthesis NSDHL,CYP2R1,LSS,SOAT2,HSD17B7,SQLEA,CEL.1,EBP,CELL,SC4MOL

    Protein Function

    DHCR7 has several biochemical functions, for example, 7-dehydrocholesterol reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHCR7 itself. We selected most functions DHCR7 had, and list some proteins which have the same functions with DHCR7. You can find most of the proteins on our site.

    Function Related Protein

    Interacting Protein

    DHCR7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHCR7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHCR7.

    TOR1A;FADS1;ILK;NDN;TNIK;q8czf9_yerpe;Cep152;15-deoxy-delta(12,14;E2F3;Atp2a2;LTN1;1C;ERBB2;Bmpr1a;Smn1;P;Hspa14;AGO2

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