DERL2

  • Official Full Name

    Der1-like domain family, member 2

  • Overview

    Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the;homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006;(PubMed 16449189)).

  • Synonyms

    DERL2;Der1-like domain family, member 2;derlin-2;CGI 101;derlin 2;F LAN 1;F LANa;FLANa;Carcinoma related;Degradation in endoplasmic reticulum protein 2;DER 2;Der1 like domain family member 2;DER2;DERL 2;Derlin2;DERtrin 2;DERtrin2;DERtrin-2;OTTHUMP00000128204;der1-like protein 2;F-LANa;CGI-101;F-LAN-1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • Mus musculus
  • Dictyostelium Discoideum
  • Pongo Abelii
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
DERL2-11941H Recombinant Human DERL2, His-tagged E.coli Human His 1-70a.a.
DERL2-1245R Recombinant Rhesus monkey DERL2 Protein, His-tagged Mammalian Cells Rhesus macaque His
DERL2-3002Z Recombinant Zebrafish DERL2 Mammalian Cells Zebrafish His
DERL2-984H Recombinant Human DERL2 Mammalian Cells Human His
DERL2-6970HCL Recombinant Human DERL2 293 Cell Lysate HEK293 Human Non
DERL2-1070R Recombinant Rhesus Macaque DERL2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
DERL2-1070R-B Recombinant Rhesus Macaque DERL2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DERL2-2389H Recombinant Human DERL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
DERL2-2791H Recombinant Human DERL2 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
DERL2-2791H-B Recombinant Human DERL2 Protein Pre-coupled Magnetic Beads HEK293 Human
Derl2-584M Recombinant Mouse Derl2 Protein, MYC/DDK-tagged HEK293 Mouse Myc&DDK
RFL24828MF Recombinant Full Length Mouse Derlin-2(Derl2) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-239)
RFL31419DF Recombinant Full Length Dictyostelium Discoideum Probable Derlin-2 Homolog(Derl2) Protein, His-Tagged E.coli Dictyostelium Discoideum His Full L. Full Length (1-254)
RFL32737HF Recombinant Full Length Human Derlin-2(Derl2) Protein, His-Tagged E.coli Human His Full L. Full Length (1-239)
RFL33857PF Recombinant Full Length Pongo Abelii Derlin-2(Derl2) Protein, His-Tagged E.coli Pongo Abelii His Full L. Full Length (1-239)

    Involved Pathway

    DERL2 involved in several pathways and played different roles in them. We selected most pathways DERL2 participated on our site, such as Asparagine N-linked glycosylation,Calnexin/calreticulin cycle,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with DERL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Asparagine N-linked glycosylation CNIH3,STT3A,TRAPPC6BL,CTSZ,NAPAA,NAPG,PPP6R1,SEC22C,GNE,ALG10B
    Calnexin/calreticulin cycle MAN1B1,OS9
    Hh mutants abrogate ligand secretion OS9
    Hh mutants that dont undergo autocatalytic processing are degraded by ERAD OS9
    Diseases of signal transduction KREMEN1,CDC37,CTBP2,MYO18A,OPN1SW,MIB1,CTBP1,RLBP1,LRRFIP1,TNKS
    ER Quality Control Compartment (ERQC) MAN1B1,OS9
    Disease TNKS2,RCC1,JAG1,AP1B1,AMN,NMT1,NUP50,AP2S1,TICAM1,PRELP
    Hedgehog ligand biogenesis NOTUM1A,HHAT,NOTUM,OS9,DISP2,SCUBE2,GPC5A

    Protein Function

    DERL2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DERL2 itself. We selected most functions DERL2 had, and list some proteins which have the same functions with DERL2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FYN,RFX1,EGR2,GP1BA,MRAP,SNRNP27,PTPRE,KSR1,ZNF69,TRPC7

    Interacting Protein

    DERL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DERL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DERL2.

    KRTAP10-7;KRTAP10-8;Dlg4;Kcnk1;Smn1;REEP5;TMEM63B;Kctd5;MASTL;Hspa14;FZD1

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