DBT
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Official Full Name
dihydrolipoamide branched chain transacylase E2 -
Overview
The branched-chain alpha-keto acid dehydrogenase complex (BCKD) is an inner-mitochondrial enzyme complex involved in the breakdown of the branched-chain amino acids isoleucine, leucine, and valine. The BCKD complex is thought to be composed of a core of 24 transacylase (E2) subunits, and associated decarboxylase (E1), dehydrogenase (E3), and regulatory subunits. This gene encodes the transacylase (E2) subunit. Mutations in this gene result in maple syrup urine disease, type 2. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. -
Synonyms
DBT;dihydrolipoamide branched chain transacylase E2;dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex;maple syrup urine disease);lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial;E2B;BCATE2;BCKAD E2 subunit;Branched chain acyltransferase, E2 component;Dihydrolipoamide branched chain transacylase;Dihydrolipoyl transacylase;Dihydrolipoyllysine residue (2 methylpropanoyl)transferase;E2;E2 component of branched chain alpha keto acid dehydrogenase complex;Lipoamide acyltransferase component of mitochondrial branched chain alpha keto acid dehydrogenase complex;Mitochondrial branched chain alpha keto acid dehydrogenase transacylase subunit (E2b);BCKADE2;BCKAD-E2;dihydrolipoyllysine-residue (2-methylpropanoyl)transferase;branched-chain alpha-keto acid dehydrogenase complex component E2;E2 component of branched chain alpha-keto acid dehydrogenase complex;mitochondrial branched chain alpha-keto acid dehydrogenase transacylase subunit (E2b);dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex;lipoamide acyltransferase component of mitochondrial branched-chain alpha-keto acid dehydrogenase complex
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Chicken
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- Insect Cells
- E.coli
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
DBT involved in several pathways and played different roles in them. We selected most pathways DBT participated on our site, such as 2-oxobutanoate degradation,2-oxobutanoate degradation I,2-oxoisovalerate decarboxylation to isobutanoyl-CoA, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| L-threonine degradation V | SDS,SDSL |
| 2-oxobutanoate degradation | DLD |
| Biosynthesis of antibiotics | PAICS,CTH,EHHADH,LDHAL6B,CS,ADH5,DAO1,DLD,ADSL,DLST |
| 2-oxoisovalerate decarboxylation to isobutanoyl-CoA | DLD |
| 2-oxobutanoate degradation I | DLD |
| Branched-chain amino acid catabolism | IVD,DLD,ALDH9A1A.2,BCKDK,HIBADHA,HIBADH,PPM1K |
Protein Function
DBT has several biochemical functions, for example, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DBT itself. We selected most functions DBT had, and list some proteins which have the same functions with DBT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | TMBIM6,RFFL,VCL,KCNQ3,MID1,UBOX5,RBX1,CASP8,CLU,ANAPC2 |
Interacting Protein
DBT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBT here. Most of them are supplied by our site. Hope this information will be useful for your research of DBT.
TNFRSF1B;ADI1;USP16;IFIT2;YBX1;ICT1;ACAD9;AGO3;AGO4;HDAC6;SIRT4;Hdac6
Resources
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References
- Cato, A; Celada, L; et al. Brominated flame retardants, tetrabromobisphenol A and hexabromocyclododecane, activate mitogen-activated protein kinases (MAPKs) in human natural killer cells. CELL BIOLOGY AND TOXICOLOGY 30:345-360(2014).
- Celada, LJ; Whalen, MM; et al. Effects of butyltins on mitogen-activated-protein kinase kinase kinase and Ras activity in human natural killer cells. JOURNAL OF APPLIED TOXICOLOGY 34:1002-1011(2014).
