DBH
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Official Full Name
dopamine beta-hydroxylase (dopamine beta-monooxygenase) -
Overview
Dopamine β-hydroxylase (DBH) is an enzyme that converts dopamine to norepinephrine. DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor. It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. DBH is inhibited by disulfiram, tropolone, and, most selectively, by nepicastat. -
Synonyms
DBH;dopamine beta-hydroxylase (dopamine beta-monooxygenase);dopamine beta-hydroxylase;DBM
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Bovine
- E.coli
- HEK293
- CHO
- Wheat Germ
- Mammalian Cells
- Human Cells
- Yeast
- GST
- His
- Non
- His&T7
- Flag
- DDK&Myc
- His&MBP
- Avi&Fc&His
Involved Pathway
DBH involved in several pathways and played different roles in them. We selected most pathways DBH participated on our site, such as Amine-derived hormones,Biogenic Amine Synthesis,Catecholamine biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Catecholamine biosynthesis | MOXD2,DDC |
| Monoamine Transport | TPH2,SCAMP2,TGFB1I1,SYN1,FBXO32,HRH3,UNC13B |
| Metabolism of amino acids and derivatives | CKBA,CKMT1B,SLC6A12,DIO2,HIBADHA,GLS2B,TPH2,DAO,OAZ2B,FTCD |
| Metabolism | SLC25A14,AKR1C4,TIAM2,PLCD3,DDAH1,CYP3A7,INSIG1,FIG4,DLAT,PPM1K |
| Biogenic Amine Synthesis | DDC,COMT,CHAT |
| Metabolic pathways | DNMT3B,COQ2,CHPT1,CBS,HPSE2,SPTLC1,ACSL4A,ALOX15B,ALPL,ACOT2 |
| Amine-derived hormones | DIO2,CGA,TPH2,DDC |
| Tyrosine metabolism | ALDH3A1,ADH2-2,FAHD1,AOX3,GOT2A,GSTZ1,GOT2B,TAT,AOX4,TYRP1 |
Protein Function
DBH has several biochemical functions, for example, L-ascorbic acid binding,catalytic activity,copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DBH itself. We selected most functions DBH had, and list some proteins which have the same functions with DBH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| catalytic activity | TIGARB,DDAH1,ACSL4A,LYZ1,PHKB,ETNPPL,CPS1,ACSL3A,SPTLC2B,GLULA |
| L-ascorbic acid binding | EGLN2,EGLN3,OGFOD1,P3H2,P4HA1A,PLOD2,PLOD3,EGLN1,TMLHE,OGFOD3 |
| copper ion binding | F5,PAM,S100A5,LOXL2A,SNAI3,LOXL2,COX17,ABP1,SOD1,ADNP |
Interacting Protein
DBH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBH here. Most of them are supplied by our site. Hope this information will be useful for your research of DBH.
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References
- Flak, JN; Myers, B; et al. Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress. EUROPEAN JOURNAL OF NEUROSCIENCE 39:1903-1911(2014).
- Lin, LH; Moore, SA; et al. Astrocytes in the Rat Nucleus Tractus Solitarii Are Critical for Cardiovascular Reflex Control. JOURNAL OF NEUROSCIENCE 33:18608-18617(2013).
