CYP4F2
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Official Full Name
cytochrome P450, family 4, subfamily F, polypeptide 2 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. -
Synonyms
CYP4F2;cytochrome P450, family 4, subfamily F, polypeptide 2;cytochrome P450, subfamily IVF, polypeptide 2;leukotriene-B(4) omega-hydroxylase 1;CYPIVF2;cytochrome P450 4F2;cytochrome P450-LTB-omega;leukotriene-B4 20-monooxygenase;leukotriene B4 om
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP4F2-555H | Active Recombinant Human CYP4F2 | Insect Cells | Human | Non |
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| CYP4F2-10H | Active Recombinant Human CYP4F2 Protein | E.coli | Human |
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| CYP4F2-1302H | Recombinant Human CYP4F2 Protein, His-tagged | E.coli | Human | His | Met1-Asp252 |
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| CYP4F2-301409H | Recombinant Human CYP4F2 protein, GST-tagged | E.coli | Human | GST | Met251-Thr324 |
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| CYP4F2-85H | Recombinant Human CYP4F2 Protein | E.coli | Human |
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Involved Pathway
CYP4F2 involved in several pathways and played different roles in them. We selected most pathways CYP4F2 participated on our site, such as Arachidonic acid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | DLAT,ENO2,R05D11.9,DNMT3,GCLM,IDH1,IVD,FUT8,PHOSPHO1,ALG3 |
| Arachidonic acid metabolism | CYP2C55,PLA2G16,AWAT2,CYP2C54,ALOX15,FAAH2B,CYP2C37,LTC4S,CYP4A12A,GGT1A |
Protein Function
CYP4F2 has several biochemical functions, for example, alkane 1-monooxygenase activity,alpha-tocopherol omega-hydroxylase activity,arachidonic acid epoxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F2 itself. We selected most functions CYP4F2 had, and list some proteins which have the same functions with CYP4F2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP26B1,CYP1D1,CYP2A4,CYP2AA9,CYP4A10,CYP2C9,HBAA1,CYP2C38,CYP8B1,NOS3 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | POR,CYP11C1,MICAL1,CYP11B1,CYP4F11,COQ6,MICAL2,MTRR,NDOR1,CYP4F18 |
| alkane 1-monooxygenase activity | CYP4F12,CYP4A14,CYP4A12A,CYP4A10,CYP4F18,CYP4A11 |
| protein binding | TBX5,ITK,FAM127C,CREB3L1,TNPO2,LILRB2,TACC3,BIRC7,THEMIS2,PALM |
| alpha-tocopherol omega-hydroxylase activity | CYP4F3,CYP4F14,CYP4F18 |
| tocotrienol omega-hydroxylase activity | MICAL2B,MICAL2,CYP4F18 |
| arachidonic acid omega-hydroxylase activity | CYP4F18,CYP4A14,CYP4A10 |
| iron ion binding | CYP2AA9,FDX1,BA1,HBBE3,CYP26B1,CYP2A6,CYP1A4,HBB-BH1,CYP2AD2,CYP2F1 |
| leukotriene-B4 20-monooxygenase activity | CYP4F18,CYP4F12,CYP4F3,CYP4A11,CYP4F14,CYP4A10 |
Interacting Protein
CYP4F2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F2.
ABL1;FYN;SRC;NCK1;GRB2
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References
- Michaels, S; Wang, MZ; et al. The Revised Human Liver Cytochrome P450 "Pie": Absolute Protein Quantification of CYP4F and CYP3A Enzymes Using Targeted Quantitative Proteomics. DRUG METABOLISM AND DISPOSITION 42:1241-1251(2014).
- Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
