CYP4F12
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Official Full Name
cytochrome P450, family 4, subfamily F, polypeptide 12 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. -
Synonyms
CYP4F12;cytochrome P450, family 4, subfamily F, polypeptide 12;cytochrome P450, subfamily IVF, polypeptide 12;cytochrome P450 4F12;CYPIVF12;F22329_1
Recombinant Proteins
- Rhesus macaque
- Human
- Cynomolgus
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
CYP4F12 involved in several pathways and played different roles in them. We selected most pathways CYP4F12 participated on our site, such as Biological oxidations,Cytochrome P450 - arranged by substrate type,Eicosanoids, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tryptophan metabolism | AANAT1,DHCR24,HADHAB,TPH1,AANAT,TPH1A,AADAT,IL4I1,HADHAA,CCBL2 |
| Metabolism | SLC25A21,DGUOK,CYP2A7,NUDT3,SLC25A15,COX4I1,CYP4B1,GPAT2,INSIG2,CPTP |
| Cytochrome P450 - arranged by substrate type | CYP4F11,CYP51A1,CYP2Y3,CYP2C18,CYP2E1,CYP4T8,CYP3A7-CYP3AP1,FDXR,CYP3C1,CYP2C9 |
| cytochrome P450 | POR,CYP2W1,CYB5A,CYB5R3,CYP4Z1,CYP2A7,CYP4V2,CYB5B,CYP20A1 |
| Phase 1 - Functionalization of compounds | CYP3C1,CYP8B2,CYP2K22,AADAC,CYP2A7,CYP2AD6,CYP2U1,CYP2AD3,CYP4T8,CYP3C4 |
| Fatty acids | CYP2N13,CYP2A13,CYP2V1,CYP2F1,CYP4A11,CYP2AD6,CYP4F22,CYP2AD2,CYP2J2,CYP2A7 |
| Biological oxidations | CYP11A1,CYP2C9,CYP2V1,ACSM1,CYP4B1,CYP4F11,CYP3C4,CYP2J2,CYP11B1,GGT6 |
| Eicosanoids | CYP4F11,CYP4F22,CYP4B1,CYP4A11 |
Protein Function
CYP4F12 has several biochemical functions, for example, alkane 1-monooxygenase activity,arachidonic acid epoxygenase activity,aromatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F12 itself. We selected most functions CYP4F12 had, and list some proteins which have the same functions with CYP4F12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP19A1A,CYP4A10,CYP2K18,PTGS2B,CYP2K19,CYP4F22,CYP2C9,HMOX1,CYP2X10.2,FAM84B |
| iron ion binding | TPH2,CYP1A4,TPH1B,ETHE1,CYP2J2,HBAD,CYP4F11,CYP4B1,TPH1A,NOS2B |
| alkane 1-monooxygenase activity | CYP4A14,CYP4F18,CYP4A11,CYP4A12A,CYP4A10,CYP4F2 |
| aromatase activity | CYP1D1,CYP3A43,CYP2J2,CYP4B1,CYP2C50,CYP4Z1,CYP2C38,FAM84B,CYP1B1,CYP19A1 |
| arachidonic acid epoxygenase activity | CYP2Y3,CYP2J5,CYP2AA2,CYP2J2,CYP2P10,CYP2AA1,CYP4A10,CYP2A6,CYP2C38,CYP2P9 |
| leukotriene-B4 20-monooxygenase activity | CYP4F18,CYP4A11,CYP4A10,CYP4F14,CYP4F2,CYP4F3 |
Interacting Protein
CYP4F12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F12.
saicar;PKM;SOD2;HSPA6
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References
- Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).
- Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
