CYP3A43
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Official Full Name
cytochrome P450, family 3, subfamily A, polypeptide 43 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms. -
Synonyms
CYP3A43;cytochrome P450, family 3, subfamily A, polypeptide 43;cytochrome P450, subfamily IIIA, polypeptide 43;cytochrome P450 3A43;Cytochrome P450 family 3 subfamily A polypeptide 43;Cytochrome P450 polypeptide 43;Cytochrome P450 subfamily IIIA polypeptide 43;MGC119315;MGC119316
Recombinant Proteins
- Rhesus macaque
- Human
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- HEK293
- His
- GST
- Non
- N-His&C-Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP3A43-1159R | Recombinant Rhesus monkey CYP3A43 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| CYP3A43-2275H | Recombinant Human CYP3A43 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYP3A43-437HCL | Recombinant Human CYP3A43 cell lysate | Human | Non |
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| CYP3A43-2434HF | Recombinant Full Length Human CYP3A43 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 280 amino acids |
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| CYP3A43-4333H | Recombinant Human CYP3A43 protein, His&Myc-tagged | E.coli | Human | N-His&C-Myc | 1-393aa |
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| CYP3A43-984R | Recombinant Rhesus Macaque CYP3A43 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CYP3A43-984R-B | Recombinant Rhesus Macaque CYP3A43 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
CYP3A43 involved in several pathways and played different roles in them. We selected most pathways CYP3A43 participated on our site, such as Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A43 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | NAT2,GSTM2,GSTA5,CCBL1,CYP2C70,UGT1A6,PTGS2,GSTP2,GSTA3,ADH4 |
Protein Function
CYP3A43 has several biochemical functions, for example, aromatase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A43 itself. We selected most functions CYP3A43 had, and list some proteins which have the same functions with CYP3A43. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP46A1.3,HBAA,CYB5A,CYP11A1,CYP2J5,CYP8B2,CYP4F12,IDO2,CYP19A1B,CYP2X8 |
| iron ion binding | HBQ1,PPEF2,LEPREL2,Scd1,CYP2C55,HBBE3,NOS2A,CYP7A1,CYP2P6,CYP3C4 |
| aromatase activity | CYP4X1,CYP4A12A,CYP2C39,CYP2D10,CYP4Z1,CYP2A12,CYP1D1,CYP3A4,CYP4B1,CYP2D26 |
| monooxygenase activity | MOXD2,CYP39A1,YWHAQB,CYP2C19,CYP4T8,CYP2K6,CYP2C9,CYP2AD6,FAM84B,CYP2K17 |
Interacting Protein
CYP3A43 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A43 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A43.
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