CYP27A1
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Official Full Name
cytochrome P450, family 27, subfamily A, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. -
Synonyms
CYP27A1;cytochrome P450, family 27, subfamily A, polypeptide 1;CYP27, cytochrome P450, subfamily XXVIIA (steroid 27 hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1;sterol 26-hydroxylase, mitochondrial;cerebrotendinous xanthomatosis;CP27;CTX;Sterol 26 hydroxylase;Sterol 27 hydroxylase;Vitamin D(3) 25hydroxylase;CYP;CYP27;Cytochrome P450 27 mitochondrial;cytochrome P450 27;sterol 27-hydroxylase;cytochrome P-450C27/25;vitamin D(3) 25-hydroxylase;cholestanetriol 26-monooxygenase;5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase;5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase;5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase;cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&GST
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CYP27A1 involved in several pathways and played different roles in them. We selected most pathways CYP27A1 participated on our site, such as Bile acid and bile salt metabolism,Biological oxidations,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP27A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPAR signaling pathway | CPT1C,FABP6,APOA2,GK2,PLIN1,RXRAA,ACSL3B,APOA1,PPARA,CYP4A14 |
| Metabolism of lipids and lipoproteins | ABHD3,MED15,ACSF3,GLTPA,ARSH,SLCO1B1,ABHD4,CTGF,SACM1L,ACOT13 |
| Bile acid and bile salt metabolism | SLCO1B1,NCOA2,SLC27A5,BRSK2,SLC27A2A,AKR1C4,Alb,CYP8B2,AKR1C21,AKR1C6 |
| Cytochrome P450 - arranged by substrate type | CYP2D6,CYP2A6,CYP2V1,CYP21A2,CYP2AD3,CYP2F1,FAM84B,CYP11B2,FDX1,CYP2K6 |
| Metabolism | SLCO1B1,CYP2K22,COX7C,SACM1L,ARSH,NAT2,SLC46A1,APOA4B.1,HAS3,G0S2 |
| Metabolic pathways | GBGT1,TDO2B,PRODH,MDH1AA,ATP5B,CYP3A25,AHCY,COQ2,COQ5,AGPAT5 |
| Endogenous sterols | CYP7A1,CYP11B1,FDX1L,CYP1B1,CYP11B2,CYP17A1,CYP46A1,FDX1,CYP51A1,CYP19A1 |
| Biological oxidations | FDXR,ADH1A,AHCY,CYP21A2,CYP2AD6,GGT6,ADH1B,Sult2a2,NAT2,SULT1ST5 |
Protein Function
CYP27A1 has several biochemical functions, for example, cholestanetriol 26-monooxygenase activity,cholesterol 26-hydroxylase activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP27A1 itself. We selected most functions CYP27A1 had, and list some proteins which have the same functions with CYP27A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| vitamin D3 25-hydroxylase activity | CYP2R1,CYP3A4,FAM84B |
| iron ion binding | CYP1A1,HBB,CYGB1,TYW1,CYP3C1L2,CYP2P8,CYP2D26,TMLHE,CYP2P7,CYP4F14 |
| steroid hydroxylase activity | CYP2AA3,CYP2R1,CYP46A1.2,CYP2D6,CYP2W1,CYP46A1.3,CYP2AD3,CYP2C38,CYP2C37,CYP2J2 |
| heme binding | CYP2J2,CYP24A1,FAM84B,PTGS2B,CYGB,HBAA,CYP2C38,EIF2AK1,CYP4X1,STC2 |
Interacting Protein
CYP27A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP27A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP27A1.
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