CYP21A2
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Official Full Name
cytochrome P450, family 21, subfamily A, polypeptide 2 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CYP21A2;cytochrome P450, family 21, subfamily A, polypeptide 2;CYP21, CYP21B, cytochrome P450, subfamily XXIA (steroid 21 hydroxylase, congenital adrenal hyperplasia), polypeptide 2;steroid 21-hydroxylase;CA21H;CAH1;CPS1;P450c21B;Steroid 21 monooxygenase;CYP21;CYP21B;P450 C21;P450 C21B;Steroid 21 hydroxylase;CYP21A 2;Cytochrome P450 21;21-OHase;cytochrome P450 XXI;cytochrome P450-C21B;steroid 21-monooxygenase;cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CYP21A2 involved in several pathways and played different roles in them. We selected most pathways CYP21A2 participated on our site, such as Aldosterone synthesis and secretion,Biological oxidations,Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP21A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytochrome P450 - arranged by substrate type | CYP2V1,CYP27A1,CYP3A7-CYP3AP1,CYP2AD3,CYP11B1,CYP11A1,CYP4B1,CYP2C8,CYP4T8,CYP2D6 |
| Corticotropin-releasing hormone | TCF4,ADRBK2,CRHR1,CYP11B1,TBX19,JUND,IVL,CRHBP,TRIM28,JUNB |
| Mineralcorticoid Metabolism | AKR1C21,CYP17A1,CYP11B2 |
| amp | AKR1C21,CYP11B2,CYP17A1 |
| Metabolic pathways | UQCRC1,NT5C3L,PANK4,ATP5D,ATP6V1E1,ATP6V1G3,DHDPSL,ME3,ATP6V1E1B,CYP2C45 |
| Glucocorticoid biosynthesis | CYP17A1,CYP11B2,CYP11B1 |
| Aldosterone synthesis and secretion | HSD3B5,GNAS,PLCB3,AKR1C1,NETO2,PLCB4,SLC14A2,CAMK1G,PRKCG,SCARB1 |
| Biological oxidations | CYP2K18,CYP2C8,CYP51A1,ADH7,CYP4T8,CYP2C9,SULT4A1,CYP3A7,AS3MT,CYP11B1 |
| Endogenous sterols | CYP11B1,CYP46A1,FDXR,CYP8B2,CYP1B1,CYP19A1,CYP11B2,CYP11A1,FDX1L,CYP7A1 |
Protein Function
CYP21A2 has several biochemical functions, for example, heme binding,iron ion binding,steroid 21-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP21A2 itself. We selected most functions CYP21A2 had, and list some proteins which have the same functions with CYP21A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| steroid 21-monooxygenase activity | CYP21A1 |
| heme binding | CYP4V7,CYP11B1,EPX,CYP2AD6,HBB-B2,CYP3A4,FAM84B,CYP4A10,SDHDA,HBAA1 |
| steroid hydroxylase activity | CYP2D6,CYP2C70,CYP2K17,CYP2C54,CYP2D10,CYP2A13,CYP2S1,CYP2D26,CYP2X7,CYP2C38 |
| steroid binding | PGRMC2,ESR2A,CYP3A4,PGRMC1,PAQR7,ESRRGA,SULT1E1,ESRRG,ESRRB,ESR1 |
| iron ion binding | CYP2AA6,FTL,CYP7A1A,CYP7B1,CYP2N13,CYP1C1,OGFOD3,CYP2K18,CYP2C19,TH2 |
Interacting Protein
CYP21A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP21A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP21A2.
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