CYP17A1
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Official Full Name
cytochrome P450, family 17, subfamily A, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. -
Synonyms
CYP17A1;cytochrome P450, family 17, subfamily A, polypeptide 1;CYP17, cytochrome P450, subfamily XVII (steroid 17 alpha hydroxylase), adrenal hyperplasia;steroid 17-alpha-hydroxylase/17,20 lyase;CPT7;P450C17;S17AH;Steroid 17 alpha monooxygenase;20 lyase;CP17A_HUMAN;CYP17;CYPXVII;Cytochrome P450 17A1;Cytochrome P450 family 17;Cytochrome P450 family 17 subfamily A polypeptide 1;Cytochrome p450 XVIIA1;Cytochrome p450, subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia;Cytochrome P450-C17;Cytochrome P450c17;OTTHUMP00000020382;P450 C17;Steroid 17 alpha hydroxylase/17,20 lyase;Steroid 17-alpha-hydroxylase/17;Steroid 17-alpha-monooxygenase;cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&T7
- His&Fc&Avi
- Myc&DDK
- His&SUMO
- Flag
Involved Pathway
CYP17A1 involved in several pathways and played different roles in them. We selected most pathways CYP17A1 participated on our site, such as Androgen biosynthesis,Biological oxidations,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP17A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytochrome P450 - arranged by substrate type | CYP3A4,CYP3C4,CYP4F12,CYP2A13,CYP3A7,CYP2C19,CYP2K22,CYP2A7,CYP27A1,CYP2C18 |
| Metabolic pathways | AGPHD1,GALNS,NAT1,PLA2G6,INPP5A,AGXT2L1,PLA2G2D,ALG12,GART,MTMR7 |
| amp | AKR1C21,CYP11B2,CYP21A2 |
| Glucocorticoid & | CYP21A2,CYP11B2,AKR1C21 |
| Metabolism | CERS5,OSBP,ACAD11,SULT1C2,OAZ2B,CYP4F12,COX11,PTGR1,LMF1,CRYM |
| Mineralcorticoid Metabolism | CYP11B2,CYP21A2,AKR1C21 |
| Androgen biosynthesis | POMCB,CGA,PPP1R2 |
| Endogenous sterols | FDXR,CYP19A1,CYP7A1,POMCB,CYP11A1,CYP8B2,CYP51A1,FDX1L,CYP46A1,CYP11B1 |
| Biological oxidations | CYP3A7,Sult2a2,CYP3A5,CYP2A6,CYP2R1,CYP2B6,UGT1B4,GSTK1,GGT6,CYP2K22 |
Protein Function
CYP17A1 has several biochemical functions, for example, 17-alpha-hydroxyprogesterone aldolase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP17A1 itself. We selected most functions CYP17A1 had, and list some proteins which have the same functions with CYP17A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP4B1,BA1,CYP1A4,CYP3A43,CYP2W1,CYP2P6,CYP21A1,ABCB6,CYB5A,CYP2P9 |
| steroid 17-alpha-monooxygenase activity | CYP17A2 |
| oxygen binding | CYP2C19,CYP1B1,CYP19A1,CYP2P7,CYP2AA3,CYP2P9,CYGB1,CYGB,HBAA1,CYP2AD3 |
| iron ion binding | CYP2X8,CYP4B1,CYP4T8,ALOX5A,CALR,CH25HL2,ISCU,CYP4A11,CYP2AA2,CYP4F3 |
Interacting Protein
CYP17A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP17A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP17A1.
CHEK2;ERBB2;IGF1R;HSP90AB1;CDH1;APC;ATP5E;PTPRJ;STK11;CDO1;TIGD7;RPAIN;BARX1
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References
- Remnant, JG; Lea, RG; et al. Novel gonadal characteristics in an aged bovine freemartin. ANIMAL REPRODUCTION SCIENCE 146:1-4(2014).
- Chand, S; Mustafa, MD; et al. CYP17A1 gene polymorphisms and environmental exposure to organochlorine pesticides contribute to the risk of small for gestational age. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 180:100-105(2014).
