CYGB
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Official Full Name
cytoglobin -
Overview
This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate;hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may;be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a;retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. -
Synonyms
CYGB;cytoglobin;HGB;histoglobin;STAP;stellate cell activation associated protein;stellate cell activation-associated protein
Recombinant Proteins
- Rhesus macaque
- Rat
- Chicken
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- His&SUMO
- His&Myc
- Myc&DDK
Involved Pathway
CYGB involved in several pathways and played different roles in them. We selected most pathways CYGB participated on our site, such as Metabolism,Metabolism of nitric oxide,eNOS activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| eNOS activation | DDAH2,DDAH1,CYGB1,CYGB2,LYPLA1,ZDHHC21 |
| Metabolism | SLC25A32A,LYVE1,LMF2,THEM5,SLC35D2,LRPPRC,BPNT1,CYP3C4,ACSF2,CHST14 |
| eNOS activation and regulation | NOSTRIN,DDAH2,SPRB,NOSIP,CYGB2,CYGB1,LYPLA1,DDAH1,GCHFR,ZDHHC21 |
| Metabolism of nitric oxide | DDAH1,NOSTRIN,GCHFR,NOSIP,DDAH2,SPRB,ZDHHC21,CYGB1,LYPLA1,CYGB2 |
Protein Function
CYGB has several biochemical functions, for example, catalase activity,fatty acid peroxidase activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYGB itself. We selected most functions CYGB had, and list some proteins which have the same functions with CYGB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RAPGEF4,FBLN1,DLGAP4,PIP5K1A,HIST1H2AI,TMEM79,RASSF3,TRIM29,PRPF4B,TMEM25 |
| oxygen binding | CYP2AA1,FAM84B,CYP2X8,HBAA1,CYP2X9,CYP2E1,HBQ1,HBM,HBA2,CYP3A5 |
| oxygen transporter activity | HBQ1,CYGB1,HBD,BA1,HBB-Y,CYGB2,HBA1,HBG1,HBBE1.1,XGB |
| peroxidase activity | PTGS2B,GPX1B,GPX6,PRDX1,GPX1A,PXDN,MPX,PTGS2,IPCEF1,GPX4A |
| heme binding | FA2H,CYP26B1,CYBB,CYP2J2,CYP11A1,CYGB1,CYP2X9,CYP2X7,PTGES2,CYP3C4 |
| nitric oxide dioxygenase activity | POR |
| catalase activity | CAT,GPX7 |
| iron ion binding | CYP2J2,CYP2AD3,P4HA3,OGFOD2,CYP2K18,OGFOD3,CYP1C2,TMEM195,CYP27B1,NOS3 |
Interacting Protein
CYGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYGB here. Most of them are supplied by our site. Hope this information will be useful for your research of CYGB.
DDI1;ATP13A2
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References
- Fujita, Y; Koinuma, S; et al. Melanoma Transition Is Frequently Accompanied by a Loss of Cytoglobin Expression in Melanocytes: A Novel Expression Site of Cytoglobin. PLOS ONE 9:-(2014).
- Motoyama, H; Komiya, T; et al. Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver. LABORATORY INVESTIGATION 94:192-207(2014).
